4-[(5,6-dimethoxy-2-fluoro-1-indanon)-2-yl]methyl-1-(3-fluorobenzyl)piperidine | 290308-83-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-[(5,6-dimethoxy-2-fluoro-1-indanon)-2-yl]methyl-1-(3-fluorobenzyl)piperidine
• 英文别名: 4-[(5,6-dimethoxy-2-flouro-indanon)-2-yl]methyl-1-(3-flourobenzyl)piperidine；ER-127528 free base；2-fluoro-2-[[1-[(3-fluorophenyl)methyl]piperidin-4-yl]methyl]-5,6-dimethoxy-3H-inden-1-one
• CAS: 290308-83-7
• 化学式: C₂₄H₂₇F₂NO₃
• 分子量: 415.48
• InChiKey: JPSYSSJBQJWDKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-[(5,6-dimethoxy-2-fluoro-1-indanon)-2-yl]methyl-1-(3-fluorobenzyl)piperidine 生成 1-(3-fluorobenzyl)-4-[(5,6-dimethoxy-2-fluoro-1-indanon)-2-yl]methylpiperidine hydrochloride
  参考文献：
  名称：

  Fluorides of 4-substituted piperidine derivatives

  摘要：

  本发明提供了一种具有优异乙酰胆碱酯酶抑制作用的新型化合物。即提供了一种由以下式表示的4-取代哌啶化合物氟化物，其药用上可接受的盐或其水合物（但排除1-苄基-4-[(5,6-二甲氧基-2-氟-1-吲哚酮)-2-基]-甲基哌啶，其药用上可接受的盐和水合物）。其中R1和R2代表取代基。

  公开号：

  US06677330B1

文献信息

• Sigma receptor binding agent containing indanone derivative
  申请人：Iimura Yoichi

  公开号：US20090137629A1

  公开（公告）日：2009-05-28

  A method for treatment of a mental disorder containing the step of administering a therapeutically effective amount of a sigma receptor binding agent containing an indanone compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. The variables of formula (I) are recited in the present specification.

  一种治疗精神障碍的方法，包括以下步骤：给予治疗有效量的sigma受体结合剂，该结合剂包含以下式子（I）所表示的indanone化合物，其药理学上可接受的盐或水合物。式子（I）的变量在本说明书中已列出。
• SIGMA RECEPTOR BINDER CONTAINING INDANONE DERIVATIVE
  申请人：Eisai Co., Ltd.

  公开号：EP1468684A1

  公开（公告）日：2004-10-20

  The present invention provides an indanone derivative and an excellent sigma receptor binding agent comprising an indanone derivative. More specifically, it provides a sigma receptor binding agent comprising an indanone derivative represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate of them. In the formula (I), R1, R2, R3 and R4 are the same as or different from each other and each represents hydrogen atom, a halogen atom, hydroxyl group, nitrile group, a C1-6 alkyl group which may be substituted, a cycloalkyl group having three to eight carbon atoms which may be substituted, a C1-6 alkoxy group which may be substituted, a cycloalkoxy group having three to eight carbon atoms which may be substituted, an acyl group having one to six carbon atoms which may be substituted, a C1-6 alkoxycarbonyl group which may be substituted, a C1-6 alkylaminocarbonyloxy group which may be substituted, a di(C1-6 alkyl)aminocarbonyloxy group which may be substituted, nitro group, an amino group which may be substituted, an amido group which may be substituted, mercapto group or a thio-C1-6 alkoxy group which may be substituted, and further R1 with R2, R2 with R3, or R3 with R4 may together form an aliphatic ring, an aromatic ring, a heterocyclic ring or an alkylenedioxy ring; the partial structure: represents a group represented by >CH-CH2-, >C=CH- or >C(-R7)-CH2-; m represents an integer of 0 or 1 to 5; and R5 represents hydrogen atom, a C1-6 alkyl group which may be substituted, a C2-6 alkenyl group which may be substituted, a C2-6 alkynyl group which may be substituted, a cycloalkyl group having three to eight carbon atoms which may be substituted, a 2,2-(alkylenedioxy)ethyl group or a group represented by the formula: (wherein the ring C represents benzene ring, an aliphatic ring or a heterocyclic ring; R6s are the same as or different from each other and each represents hydrogen atom, a halogen atom, hydroxyl group, nitrile group, a C1-6 alkyl group which may be substituted, a C2-6 alkenyl group which may be substituted, a C2-6 alkynyl group which may be substituted, a cycloalkyl group having three to eight carbon atoms which may be substituted, a C1-6 alkoxy group which may be substituted, a C1-6 alkoxyalkoxy group which may be substituted, an aryloxy group which may be substituted or an aralkyloxy group which may be substituted, and further two of R6s may together form an aliphatic ring, an aromatic ring, a heterocyclic ring or an alkylenedioxy ring; R7 represents a halogen atom, hydroxyl group, a C1-6 alkyl group which may be substituted, a C1-6 alkoxy group, nitrile group, a halogeno-C1-6 alkyl group, a hydroxyl-C1-6 alkyl group, a cyano-C1-6 alkyl group, an amino-C1-6 alkyl group, nitro group, azide group, an amino group which may be substituted, a carbamoyl group which may be substituted, a carboxyl group which may be substituted, mercapto group or a thio-C1-6 alkoxy group; and n represents an integer of 1 to 5), provided that 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine, a pharmacologically acceptable salt thereof or a hydrate of them are excluded.

  本发明提供了一种茚满酮衍生物和一种包含茚满酮衍生物的优良σ受体结合剂。更具体地说，本发明提供了一种σ受体结合剂，它由下式所代表的茚酮衍生物、其药理学上可接受的盐或它们的水合物组成。 在式 (I) 中，R1、R2、R3 和 R4 彼此相同或不同，各自代表氢原子、卤素原子、羟基、腈基、可被取代的 C1-6 烷基、具有三至八个碳原子且可被取代的环烷基、可被取代的 C1-6 烷氧基、具有三至八个碳原子且可被取代的环烷氧基、具有一至六个碳原子且可被取代的酰基、可被取代的 C1-6 烷氧基羰基、可被取代的 C1-6 烷基氨基羰氧基、可被取代的二（C1-6 烷基）氨基羰氧基、硝基、可被取代的氨基、可被取代的酰胺基、巯基或可被取代的硫代-C1-6 烷氧基，此外，R1 与 R2、R2 与 R3 或 R3 与 R4 可共同形成脂肪环、芳香环、杂环或烷基二氧基环；部分结构： 代表由 >CH-CH2-、>C=CH- 或 >C(-R7)- -代表的基团；m 代表 0 或 1 至 5 的整数；R5 代表氢原子、可被取代的 C1-6 烷基、可被取代的 C2-6 烯基、可被取代的 C2-6 烷基、可被取代的具有 3 至 8 个碳原子的环烷基、2,2-(烷基二氧基)乙基或由式...代表的基团： (其中环 C 代表苯环、脂肪环或杂环；R6s 彼此相同或不同，各自代表氢原子、卤素原子、羟基、腈基、可被取代的 C1-6 烷基、可被取代的 C2-6 烯基、可被取代的 C2-6 烷基、具有三至八个碳原子的可被取代的环烷基、可被取代的 C1-6 烷氧基、可被取代的 C1-6 烷氧基、可被取代的芳氧基或可被取代的芳烷氧基，另外两个 R6 可共同形成脂肪环、芳香环、杂环或烷二氧基环；R7 代表卤素原子、羟基、可被取代的 C1-6 烷基、C1-6 烷氧基、腈基、卤素-C1-6 烷基、羟基-C1-6 烷基、氰基-C1-6 烷基、氨基-C1-6 烷基、硝基、叠氮基、可被取代的氨基、可被取代的氨基甲酰基、可被取代的羧基、巯基或硫代-C1-6 烷氧基；和 n 代表 1 至 5 的整数），但不包括 1-苄基-4-[(5,6-二甲氧基-1-茚酮)-2-基]甲基哌啶、其药理学上可接受的盐或它们的水合物。
• Use of anti-connexin agents for enhancing the therapeutic effect of acetylcholinesterase inhibitor
  申请人：Commissariat à l'Énergie Atomique et aux Énergies Alternatives

  公开号：EP2586436A1

  公开（公告）日：2013-05-01

  This invention relates to improvements in therapeutic neurological and neuropsychic treatments using acetylcholinesterase inhibitors. More specifically, the invention enables the effects of the reversible acetylcholinesterase inhibitor donepezil to be potentiated by certain molecules, referred to here as connexin-blocking agents. Said connexin-blocking agent is preferably meclofenamic acid.

  本发明涉及使用乙酰胆碱酯酶抑制剂对神经和神经心理治疗的改进。更具体地说，本发明使可逆性乙酰胆碱酯酶抑制剂多奈哌齐的作用能够通过某些分子（在此称为连接蛋白阻断剂）得到增强。所述附着素阻断剂最好是甲氯芬那酸。
• Use of anti-connexin agents for enhancing the therapeutic effect of acetylcholinesterase inhibitors
  申请人：COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

  公开号：US10765670B2

  公开（公告）日：2020-09-08

  This invention relates to improvements in therapeutic neurological and neuropsychic treatments using acetylcholinesterase inhibitors. More specifically, the invention enables the effects of the reversible acetylcholinesterase inhibitor donepezil to be potentiated by certain molecules, referred to here as connexin-blocking agents. Said connexin-blocking agent is preferably meclofenamic acid.

  本发明涉及使用乙酰胆碱酯酶抑制剂对神经和神经心理治疗的改进。更具体地说，本发明使可逆性乙酰胆碱酯酶抑制剂多奈哌齐的作用能够通过某些分子（在此称为连接蛋白阻断剂）得到增强。所述附着素阻断剂最好是甲氯芬那酸。
• Sigma receptor binder containing indanone derivative
  申请人：Iimura Yoichi

  公开号：US20050107432A1

  公开（公告）日：2005-05-19

  The present invention provides an indanone derivative and an excellent sigma receptor binding agent comprising an indanone derivative. More specifically, it provides a sigma receptor binding agent comprising an indanone derivative represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate of them. In the formula (I), R 1 , R 2 , R 3 and R 4 are the same as or different from each other and each represents hydrogen atom, a halogen atom, hydroxyl group, nitrile group, a C 1-6 alkyl group which may be substituted, a cycloalkyl group having three to eight carbon atoms which may be substituted, a C 1-6 alkoxy group which may be substituted, a cycloalkoxy group having three to eight carbon atoms which may be substituted, an acyl group having one to six carbon atoms which may be substituted, a C 1-6 alkoxycarbonyl group which may be substituted, a C 1-6 alkylaminocarbonyloxy group which may be substituted, a di(C 1-6 alkyl)aminocarbonyloxy group which may be substituted, nitro group, an amino group which may be substituted, an amido group which may be substituted, mercapto group or a thio-C 1-6 alkoxy group which may be substituted, and further R 1 with R 2 , R 2 with R 3 , or R 3 with R 4 may together form an aliphatic ring, an aromatic ring, a heterocyclic ring or an alkylenedioxy ring; the partial structure: represents a group represented by >CH—CH 2 —, >C═CH— or >C(—R 7 )—CH 2 —; m represents an integer of 0 or 1 to 5; and R 5 represents hydrogen atom, a C 1-6 alkyl group which may be substituted, a C 2-6 alkenyl group which may be substituted, a C 2-6 alkynyl group which may be substituted, a cycloalkyl group having three to eight carbon atoms which may be substituted, a 2,2-(alkylenedioxy)ethyl group or a group represented by the formula: (wherein the ring C represents benzene ring, an aliphatic ring or a heterocyclic ring; R 6 s are the same as or different from each other and each represents hydrogen atom, a halogen atom, hydroxyl group, nitrile group, a C 1-6 alkyl group which may be substituted, a C 2-6 alkenyl group which may be substituted, a C 2-6 alkynyl group which may be substituted, a cycloalkyl group having three to eight carbon atoms which may be substituted, a C 1-6 alkoxy group which may be substituted, a C 1-6 alkoxyalkoxy group which may be substituted, an aryloxy group which may be substituted or an aralkyloxy group which may be substituted, and further two of R 6 s may together form an aliphatic ring, an aromatic ring, a heterocyclic ring or an alkylenedioxy ring; R 7 represents a halogen atom, hydroxyl group, a C 1-6 alkyl group which may be substituted, a C 1-6 alkoxy group, nitrile group, a halogeno-C 1-6 alkyl group, a hydroxyl-C 1-6 alkyl group, a cyano-C 1-6 alkyl group, an amino-C 1-6 alkyl group, nitro group, azide group, an amino group which may be substituted, a carbamoyl group which may be substituted, a carboxyl group which may be substituted, mercapto group or a thio-C 1-6 alkoxy group; and n represents an integer of 1 to 5), provided that 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine, a pharmacologically acceptable salt thereof or a hydrate of them are excluded.

  本发明提供了一种茚满酮衍生物和一种包含茚满酮衍生物的优良σ受体结合剂。更具体地说，本发明提供了一种σ受体结合剂，它包含下式所代表的茚满酮衍生物、其药理学上可接受的盐或它们的水合物。 在式 (I) 中，R 1 , R 2 , R 3 和 R 4 相同或不同，且各自代表氢原子、卤素原子、羟基、腈基、C 1-6 烷基（可被取代）、具有三至八个碳原子的环烷基（可被取代）、C 1-6 1-6 可被取代的 C 1-6 烷氧基、具有三至八个碳原子且可被取代的环烷氧基、具有一至六个碳原子且可被取代的酰基、C 1-6 1-6 烷氧基羰基（可被取代）、C 1-6 烷基氨基羰氧基（可被取代）、二（C 1-6 1-6 烷基）氨基羰氧基（可被取代）、硝基、氨基（可被取代）、酰胺基（可被取代）、巯基或硫代-C 1-6 1-6 烷氧基（可被取代），以及进一步的 R 1 与 R 2 , R 2 与 R 3 或 R 3 与 R 4 可共同形成脂肪族环、芳香族环、杂环或烷基二氧基环； 部分结构： 代表一个由 >CH-CH 2 -、>C═CH- 或 >C(-R 7 ) -CH 2 -代表 0 或 1 至 5 的整数；以及 R 5 代表氢原子、C 1-6 烷基（可被取代）、C 2-6 可被取代的 C 2-6 烷基 2-6 可被取代的 C 2-6 烷基、可被取代的 C 2-6 烯基、可被取代的 C 2-6 炔基、具有 3 至 8 个碳原子的可被取代的环烷基、2,2-(亚烷基二氧基)乙基或由以下式子表示的基团： (其中环 C 代表苯环、脂肪族环或杂环； R 6 相同或不同，且各自代表氢原子、卤素原子、羟基、腈基、C 1-6 烷基（可被取代）、C 2-6 烯基（可被取代）、C 2-6 可被取代的 C 2-6 烷基、可被取代的 C 2-6 烯基、可被取代的 C 2-6 炔基、具有三至八个碳原子的环烷基、可被取代的 C 1-6 烷氧基（可被取代）、C 1-6 可被取代的 C 1-6 烷氧基、可被取代的 C 1-6 烷氧基、可被取代的芳氧基或可被取代的芳烷氧基，以及 R 6 中的两个可共同形成脂肪环、芳香环、杂环或烷基二氧基环； R 7 7 代表卤素原子、羟基、C 1-6 烷基（可被取代）、C 1-6 烷氧基、腈基、卤素-C 1-6 烷基、羟基-C 1-6 烷基、氰基-C 1-6 烷基、氨基-C 1-6 烷基、硝基、叠氮基、可被取代的氨基、可被取代的氨基甲酰基、可被取代的羧基、巯基或硫代-C 1-6 1-6 烷氧基；以及 n 代表 1 至 5 的整数），但不包括 1-苄基-4-[(5,6-二甲氧基-1-茚酮)-2-基]甲基哌啶、其药理学上可接受的盐或它们的水合物。