(2R,5S)-1,2,5-Trimethyl-piperidine | 1071759-90-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (2R,5S)-1,2,5-Trimethyl-piperidine
• 英文别名: (2R,5S)-1,2,5-trimethylpiperidine
• CAS: 1071759-90-4
• 化学式: C₈H₁₇N
• 分子量: 127.23
• InChiKey: IQDIAWZRBAAHNR-JGVFFNPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Therapeutic compounds and uses thereof
  申请人：GENENTECH, INC.

  公开号：US10239861B2

  公开（公告）日：2019-03-26

  The invention relates to compounds of formula (I) and salts thereof: wherein R1-R3 have any of the values defined in the specification. The compounds and salts are useful for treating PCAF mediated disorders and/or GCN5 mediated disorders. The invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, as well as and methods of using said compounds, salts, or compositions in the treatment of various disorders.

  本发明涉及式（I）化合物及其盐类： 其中 R1-R3 具有说明书中定义的任何值。这些化合物和盐可用于治疗 PCAF 介导的疾病和/或 GCN5 介导的疾病。本发明还提供了包含式（I）化合物或其药学上可接受的盐的药物组合物，以及使用所述化合物、盐或组合物治疗各种疾病的方法。
• Tricyclic gyrase inhibitors
  申请人：Merck Sharp & Dohme Corp.

  公开号：US10858360B2

  公开（公告）日：2020-12-08

  Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

  本文公开了具有式 I 结构的化合物及其药学上适用的盐、酯和原药，它们可作为抗菌有效的三环回旋酶抑制剂。 还考虑了相关的药物组合物、用途和化合物的制造方法。
• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：GENENTECH, INC.

  公开号：US20180037566A1

  公开（公告）日：2018-02-08

  The invention relates to compounds of formula (I) and salts thereof: wherein R 1 -R 3 have any of the values defined in the specification. The compounds and salts are useful for treating PCAF mediated disorders and/or GCN5 mediated disorders. The invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, as well as and methods of using said compounds, salts, or compositions in the treatment of various disorders.
• US9732083B2
  申请人：——

  公开号：US9732083B2

  公开（公告）日：2017-08-15