1-Cyclodecyl-4-phenylpiperidine | 260993-33-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Cyclodecyl-4-phenylpiperidine
• CAS: 260993-33-7
• 化学式: C₂₁H₃₃N
• 分子量: 299.5
• InChiKey: QSPADUVEOHDRCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• PIPERIDINE DERIVATIVES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1109786A1

  公开（公告）日：2001-06-27
• [EN] PIPERIDINE DERIVATIVES<br/>[FR] DERIVES DE LA PIPERIDINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2000014067A1

  公开（公告）日：2000-03-16

  The present invention relates to compounds of general formula (I), wherein R1 is tetrahydronaphtyl; or -(CH¿2?)n-C6H5-R?4¿ wherein n is 0-4 and R4 is H, lower alkyl, or lower alkoxy; or C¿5?-C12 cycloalkyl, optionally substituted by lower alkyl; R?2¿ is H, OH, lower alkoxy, lower alkenyloxy or lower alkyl; R3 is C5-C7 cycloalkyl or phenyl, optionally substituted by OH, halogen, lower alkoxy, lower alkenyloxy, lower alkyl or -O-(CH2)n-C6H5 wherein n is 0-3; and their pharmaceutically acceptable acid addition salts. The compounds of general formula (I) are suitable for the treatment of memory and attention deficits, psychiatric, neurological and physiological disorders, such as anxiety and stress disorders, depression, memory loss due to Alzheimer's disease or other dementias such as vascular dementia and AIDS dementia complex, Parkinson's disease, epilepsy and convulsions, acute and/or chronic pain conditions, withdrawal symptoms of addictive drugs and reduction of their abuse/craving, control of water balance, Na+ excretion, arterial blood pressure disorders and metabolic disorders such as obesity.