2'-O-methyl-5'-O-(monomethoxytrityl)-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidite> | 226882-02-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2'-O-methyl-5'-O-(monomethoxytrityl)-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidite>
• 英文别名: 2-(4-nitrophenyl)ethyl N-[1-[(2R,3R,4R,5R)-4-[[ethyl(propan-2-yl)amino]-[2-(4-nitrophenyl)ethoxy]phosphanyl]oxy-3-methoxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-2-oxopyrimidin-4-yl]carbamate
• CAS: 226882-02-6
• 化学式: C₅₂H₅₇N₆O₁₃P
• 分子量: 1005.03
• InChiKey: MQPJUCRRGMKNAQ-SPYHHNFMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  72
• 可旋转键数：
  23
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  221
• 氢给体数：
  1
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  2'-O-methyl-5'-O-(monomethoxytrityl)-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidite> 、 alkaline earth salt of/the/ methylsulfuric acid 生成
  参考文献：
  名称：

  Nucleotides, Part LX, Synthesis and Characterization of New 2′-O-Methylriboside 3′-O-Phosphoramidites Useful for the Solid-Phase Synthesis of 2′-O-Methyloligoribonucleotides

  摘要：

  A series of new 2'-O-methylribonucleoside 3'-O-[2-(4-nitrophenyl)ethyl dialkylphosphoramidites] 27-31, 33-38, 40-44, and 45-50 were synthesized and their stability and rc activity compared in automated oligonucleotide synthesis with the standard 2'-O-methylribonucleoside 3'-O-(beta-cyanoethyl diisopropylphosphoramidites) 32, 39, 45, and 51, respectively. The 2-(4-nitrophenyl)ethyl (npe) and 2-(3-nitrophenyl)ethoxycarbonyl (npeoc) groups were used for the protection of the base moieties.

  DOI：

  10.1002/(sici)1522-2675(19990407)82:4<614::aid-hlca614>3.0.co;2-y
• 作为产物：
  描述：

  2-(4-nitrophenyl)ethyl phosphorodichloridite 在 N,N-二异丙基乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 2.33h， 生成 2'-O-methyl-5'-O-(monomethoxytrityl)-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidite>
  参考文献：
  名称：

  Nucleotides, Part LX, Synthesis and Characterization of New 2′-O-Methylriboside 3′-O-Phosphoramidites Useful for the Solid-Phase Synthesis of 2′-O-Methyloligoribonucleotides

  摘要：

  A series of new 2'-O-methylribonucleoside 3'-O-[2-(4-nitrophenyl)ethyl dialkylphosphoramidites] 27-31, 33-38, 40-44, and 45-50 were synthesized and their stability and rc activity compared in automated oligonucleotide synthesis with the standard 2'-O-methylribonucleoside 3'-O-(beta-cyanoethyl diisopropylphosphoramidites) 32, 39, 45, and 51, respectively. The 2-(4-nitrophenyl)ethyl (npe) and 2-(3-nitrophenyl)ethoxycarbonyl (npeoc) groups were used for the protection of the base moieties.

  DOI：

  10.1002/(sici)1522-2675(19990407)82:4<614::aid-hlca614>3.0.co;2-y