3-Butylamino-piperidin | 25560-14-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-Butylamino-piperidin
• 英文别名: 3-(n-Butylamino)-piperidin；butyl-piperidin-3-yl-amine；N-butylpiperidin-3-amine
• CAS: 25560-14-9
• 化学式: C₉H₂₀N₂
• 分子量: 156.271
• InChiKey: UUBRATADBZZTPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] HETEROCYCLIC COMPOUNDS AS KINASE INHIBITOR AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE KINASE ET LEURS UTILISATIONS
  申请人：INTEGRAL BIOSCIENCES PVT LTD

  公开号：WO2021019514A1

  公开（公告）日：2021-02-04

  The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed.

  本公开涉及一般用于治疗与检查点激酶（CHK）相关疾病的化合物，特别是CHK-1酶。具体地，本发明揭示了式（IA）的化合物，该化合物对CHK-1酶具有抑制活性。公开了使用这些化合物治疗与CHK-1酶过度活性相关的疾病的方法。还公开了这些化合物的用途、制药组合物、试剂盒和合成方法。
• Process for producing 1-alkoxycarbonyl nitrogenous saturated heterocyclic derivative
  申请人：——

  公开号：US20040242888A1

  公开（公告）日：2004-12-02

  A method for producing N-protected heterocyclic compounds such as 1-alkoxycarbonyl-3-aminopyrrolidines through position-selective reaction at the nitrogen atom that constitutes the hetero ring of a nitrogen-containing saturated heterocyclic compound having two nitrogen atoms such as 3-aminopyrrolidine. A dialkyl dicarbonate (ROCO-O-COOR) is reacted with a nitrogen-containing saturated heterocyclic compounds having two nitrogen atoms, at pH of from 9 to 14 to obtain a high-purity 1-alkoxycarbonyl nitrogen-containing saturated heterocyclic compound.

  一种生产N-保护杂环化合物（例如1-烷氧羰基-3-氨基吡咯烷）的方法，通过在含有两个氮原子的氮杂环化合物（例如3-氨基吡咯烷）的杂环中构成氮原子的位置选择性反应。将双烷基碳酸酯（ROCO-O-COOR）与含有两个氮原子的氮杂环化合物在pH为9至14的条件下反应，可获得高纯度的1-烷氧羰基氮杂环化合物。
• PROCESS FOR PRODUCING 1-ALKOXYCARBONYL NITROGENOUS SATURATED HETEROCYCLIC DERIVATIVE
  申请人：Toray Fine Chemicals Co., Ltd.

  公开号：EP1460061A1

  公开（公告）日：2004-09-22

  A method for producing N-protected heterocyclic compounds such as 1-alkoxycarbonyl-3-aminopyrrolidines through position-selective reaction at the nitrogen atom that constitutes the hetero ring of a nitrogen-containing saturated heterocyclic compound having two nitrogen atoms such as 3-aminopyrrolidine. A dialkyl dicarbonate (ROCO-O-COOR) is reacted with a nitrogen-containing saturated heterocyclic compounds having two nitrogen atoms, at pH of from 9 to 14 to obtain a high-purity 1-alkoxycarbonyl nitrogen-containing saturated heterocyclic compound.

  一种通过在具有两个氮原子的含氮饱和杂环化合物（如 3-氨基吡咯烷）中构成杂环的氮原子上进行位置选择性反应来生产 N 保护杂环化合物（如 1-烷氧羰基-3-氨基吡咯烷）的方法。将二烷基二碳酸酯（ROCO-O-COOR）与具有两个氮原子的含氮饱和杂环化合物在 pH 值为 9 至 14 的条件下进行反应，可得到高纯度的 1-烷氧基羰基含氮饱和杂环化合物。
• COMPOUND CONTAINING BASIC GROUP AND USE THEREOF
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1790639A1

  公开（公告）日：2007-05-30

  The present invention relates to a compound represented by formula (I-0): wherein symbols in formula have the same meanings as described in the present specification, a salt thereof, an N-oxide thereof or a solvate thereof or a prodrug thereof, and medical use thereof The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.

  本发明涉及一种由式（I-0）表示的化合物： 其中式中符号的含义与本说明书中所述的相同、其盐、其 N-氧化物或其溶解物或其原药，以及其医疗用途 本发明的化合物对 CXCR4 具有拮抗活性，因此可用作 CXCR4 介导的疾病的预防和/或治疗剂，例如炎症性和免疫性疾病（如类风湿性关节炎、关节炎、视网膜病变、肺纤维化、移植器官排斥等）、过敏性疾病、感染、疾病性溃疡、溃疡性结肠炎等。)、过敏性疾病、感染（例如人类免疫缺陷病毒感染、获得性免疫缺陷综合征等）、精神神经疾病、脑部疾病、心血管疾病、代谢性疾病和癌症疾病（例如癌症、癌症转移等），或再生治疗剂。
• CARBAZOLE DERIVATIVES
  申请人：Bristol-Myers Squibb Company

  公开号：EP3209651B9

  公开（公告）日：2020-05-20