(1R,4S,5S,6S)-4-[2'S-tert-butoxycarbonylamino-3'-(1-tert-butoxycarbonyl-1H-indol-3-yl)propionylamino]-2,2-dioxo-2λ⁶-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid dimethyl ester | 635317-71-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1R,4S,5S,6S)-4-[2'S-tert-butoxycarbonylamino-3'-(1-tert-butoxycarbonyl-1H-indol-3-yl)propionylamino]-2,2-dioxo-2λ⁶-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid dimethyl ester
• 英文别名: dimethyl (1R,4S,5S,6S)-4-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-[1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]propanoyl]amino]-2,2-dioxo-2lambda6-thiabicyclo[3.1.0]hexane-4,6-dicarboxylate；dimethyl (1R,4S,5S,6S)-4-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-[1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]propanoyl]amino]-2,2-dioxo-2λ6-thiabicyclo[3.1.0]hexane-4,6-dicarboxylate
• CAS: 635317-71-4
• 化学式: C₃₀H₃₉N₃O₁₁S
• 分子量: 649.719
• InChiKey: PLAGHIRRMVAPHY-BBRJCEFQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  45
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  194
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• Prodrugs of excitatory amino acids
  申请人：Moher David Eric

  公开号：US20050222231A1

  公开（公告）日：2005-10-06

  This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psychiatric disorders.

  这项发明涉及合成兴奋性氨基酸前药及其制备方法。该发明还涉及使用方法和包含该化合物的药物组合物，用于治疗神经系统疾病和精神疾病。
• PRODRUGS OF EXCITATORY AMINO ACIDS
  申请人：Moher Eric David

  公开号：US20080182889A1

  公开（公告）日：2008-07-31

  This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psychiatric disorders.

  本发明涉及合成兴奋性氨基酸前药及其制备方法。本发明还涉及使用该化合物治疗神经系统疾病和精神障碍的方法和包含该化合物的药物组合物。
• Methods of Treatment Using a Prodrug of an Excitatory Amino Acid
  申请人：Moher Eric David

  公开号：US20120172422A1

  公开（公告）日：2012-07-05

  This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psychiatric disorders.

  本发明涉及合成兴奋性氨基酸前药及其制备方法。本发明还涉及使用该化合物治疗神经系统疾病和精神障碍的方法，以及包含该化合物的制药组合物。
• METHODS OF TREATMENT USING A PRODRUG OF AN EXCITATORY AMINO ACID
  申请人：Moher Eric David

  公开号：US20110207672A1

  公开（公告）日：2011-08-25

  This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psychiatric disorders.

  本发明涉及合成兴奋性氨基酸前药及其制备方法。本发明还涉及使用该化合物治疗神经系统疾病和精神障碍的方法和制药组合物。
• US7371872B2
  申请人：——

  公开号：US7371872B2

  公开（公告）日：2008-05-13