(3,4-dimethoxybenzyl)(N-benzyl-4-piperidyl-methyl)malonic acid | 259169-96-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3,4-dimethoxybenzyl)(N-benzyl-4-piperidyl-methyl)malonic acid
• 英文别名: 2-[(1-Benzylpiperidin-4-yl)methyl]-2-[(3,4-dimethoxyphenyl)methyl]propanedioic acid
• CAS: 259169-96-5
• 化学式: C₂₅H₃₁NO₆
• 分子量: 441.524
• InChiKey: RNNLHAPCNGZSMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  96.3
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL
  申请人：Manikowski Andrzej

  公开号：US20090137811A1

  公开（公告）日：2009-05-28

  The present invention relates to a new process for the preparation of intermediate compounds useful in the manufacture of donepezil, or a pharmaceutically-acceptable salt thereof, and also relates to processes for preparing donepezil and to the novel intermediates per se. In addition the invention relates to various hydrated forms of donepezil.

  本发明涉及一种新的制备中间体化合物的工艺，该中间体化合物可用于制造多奈哌齐或其药用可接受盐，并且还涉及制备多奈哌齐的工艺以及新的中间体化合物本身。此外，本发明还涉及多奈哌齐的各种水合形式。
• PROCESS AND INTERMEDIATES FOR PRODUCTION OF DONEPEZIL AND RELATED COMPOUNDS
  申请人：Finetech Ltd

  公开号：EP1129073A2

  公开（公告）日：2001-09-05
• EP1992616A1
  申请人：——

  公开号：EP1992616A1

  公开（公告）日：2008-11-19
• US6492522B1
  申请人：——

  公开号：US6492522B1

  公开（公告）日：2002-12-10
• [EN] NOVEL PROCESS AND INTERMEDIATES FOR PRODUCTION OF DONEPEZIL AND RELATED COMPOUNDS<br/>[FR] NOUVEAU PROCEDE ET INTERMEDIAIRES POUR LA PRODUCTION DE DONEPEZIL ET DE SES COMPOSES APPARENTES
  申请人：FINETECH LTD

  公开号：WO2000009483A2

  公开（公告）日：2000-02-24

  The present invention relates to a new process for the preparation of acetylcholinesterase inhibitors of formula (I) or a salt thereof, wherein: R1 is N-acyl-4-piperidyl; N-alkoxycarbonyl-4-piperidyl; 4-piperidyl; N-alkyl-4-piperidyl; N-benzyl-4-piperidyl; N-(φ-aralkyl)-4-piperidyl; 4-pyridyl; R?4, R5, R6 and R7¿ are identical or different and each represents hydrogen, straight-chain or branched alkyl, aryl, hydroxy, alkoxy, aryloxy, benzyloxy, acyloxy, alkylthio, arylthio, benzylthio, acylamino, phthalimido or halogen; n is 1, 2 or 3; m is 1, 2, 3, 4 or 5. This process comprises cyclisation of a compound of formula (II) or salts thereof, wherein R?1, R4, R5, R6 and R7¿, m and n are as defined above; R2 is selected from a derivatised or non-derivatised carboxyl, cyano, N-substituted aminocarbonyl groups or hydrogen; R3 is selected from a derivatised or non-derivatised carboxyl, cyano or N-substituted aminocarbonyl groups, optionally in the presence of acids and/or solvents. One of the most potent acetylcholinesterase inhibitors of the class of compounds prepared according to the present invention is donepezil.