(Z)-(2S,3R,8R)-3-(tert-Butyl-diphenyl-silanyloxy)-8-diisopropylsilanyloxy-2-ethyl-9-methylene-2,3,4,7,8,9-hexahydro-oxonine | 140170-13-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (Z)-(2S,3R,8R)-3-(tert-Butyl-diphenyl-silanyloxy)-8-diisopropylsilanyloxy-2-ethyl-9-methylene-2,3,4,7,8,9-hexahydro-oxonine
• CAS: 140170-13-4
• 化学式: C₃₃H₅₀O₃Si₂
• 分子量: 550.929
• InChiKey: DSQITVAJHOLMLE-ILWUSMDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.52
• 重原子数：
  38.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (Z)-(2S,3R,8R)-3-(tert-Butyl-diphenyl-silanyloxy)-8-diisopropylsilanyloxy-2-ethyl-9-methylene-2,3,4,7,8,9-hexahydro-oxonine 生成 (+/-)-(Z,2R,3R,8R,9S)-8-tert-butyldiphenylsilanyloxy-9-ethyl-3-hydroxy-2-hydroxymethyl-2,3,4,7,8,9-hexahydrooxonine 、 (2S,3R,5Z,8R,9S)-8-[tert-butyl(diphenyl)silyl]oxy-9-ethyl-2-(hydroxymethyl)-2,3,4,7,8,9-hexahydrooxonin-3-ol
  参考文献：
  名称：

  An intramolecular hydrosilation approach to hexahydrooxonins related to obtusenyne. Effect of catalyst and conditions on stereoselectivity

  摘要：

  The intramolecular hydrosilation of the alpha-dialkysilyloxy enol ethers 3 and 5 followed by oxidative work-up resulted in the diastereoselective synthesis of either the hexahydrooxonin diol 7 or 8 according to the catalyst and conditions employed.

  DOI：

  10.1016/s0040-4039(00)92340-2
• 作为产物：
  描述：

  二异丙基氯代硅烷 、 (Z,3R,8R,9S)-8-tert-butyldiphenylsilanyloxy-9-ethyl-3-hydroxy-2-methylene-2,3,4,7,8,9-hexahydrooxonine 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以92%的产率得到(Z)-(2S,3R,8R)-3-(tert-Butyl-diphenyl-silanyloxy)-8-diisopropylsilanyloxy-2-ethyl-9-methylene-2,3,4,7,8,9-hexahydro-oxonine
  参考文献：
  名称：

  An intramolecular hydrosilation approach to hexahydrooxonins related to obtusenyne. Effect of catalyst and conditions on stereoselectivity

  摘要：

  The intramolecular hydrosilation of the alpha-dialkysilyloxy enol ethers 3 and 5 followed by oxidative work-up resulted in the diastereoselective synthesis of either the hexahydrooxonin diol 7 or 8 according to the catalyst and conditions employed.

  DOI：

  10.1016/s0040-4039(00)92340-2