3-(N-benzyl-4-piperidinyl)-2-(3-phenoxyphenyl)thiazolidin-4-one | 491864-90-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(N-benzyl-4-piperidinyl)-2-(3-phenoxyphenyl)thiazolidin-4-one
• 英文别名: 3-(1-Benzylpiperidin-4-yl)-2-(3-phenoxyphenyl)-1,3-thiazolidin-4-one
• CAS: 491864-90-5
• 化学式: C₂₇H₂₈N₂O₂S
• 分子量: 444.598
• InChiKey: MMOXEXNVAXJSQF-UHFFFAOYSA-N

物化性质

• 沸点：
  618.9±55.0 °C(Predicted)
• 密度：
  1.234±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  58.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Aryl substituted thiazolidinones and the use thereof
  申请人：Euro-Celtique, S.A.

  公开号：US20030109521A1

  公开（公告）日：2003-06-12

  This invention relates aryl substituted thiazolidinones of Formula I: 1 or a pharmaceutically acceptable salt, or solvate thereof, wherein R 1 and R 2 , are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

  本发明涉及式 I 的芳基取代的噻唑烷酮： 1 或其药学上可接受的盐或溶液，其中 R 1 和 R 2 的定义见说明书。本发明还涉及式 I 化合物在以下方面的用途：治疗全局性和局灶性缺血后的神经元损伤；治疗或预防神经退行性疾病，如肌萎缩性脊髓侧索硬化症（ALS）；治疗、预防或改善急性或慢性疼痛；用作抗耳鸣剂、抗惊厥剂、抗躁狂抑制剂、局部麻醉剂、抗心律失常剂以及治疗或预防糖尿病神经病变。
• ARYL SUBSTITUTED THIAZOLIDINONES AND THE USE THEREOF
  申请人：EURO-CELTIQUE S.A.

  公开号：EP1417187A1

  公开（公告）日：2004-05-12
• Aryl substituted thiazinidinones and the use thereof
  申请人：Euro-Celtique S.A.

  公开号：US20040176364A1

  公开（公告）日：2004-09-09

  This invention relates aryl substituted thiazolidinones of Formula I: 1 or a pharmaceutically acceptable salt, or solvate thereof, wherein R 1 and R 2 , are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
• US7169782B2
  申请人：——

  公开号：US7169782B2

  公开（公告）日：2007-01-30
• [EN] ARYL SUBSTITUTED THIAZOLIDINONES AND THE USE THEREOF<br/>[FR] THIAZOLIDINONES A SUBSTITUTION ARYLE ET UTILISATIONS
  申请人：EURO CELTIQUE SA

  公开号：WO2003008398A1

  公开（公告）日：2003-01-30

  This invention relates aryl substituted thiazolidinones of Formula I: (I) or a pharmaceutically acceptable salt, or solvate thereof, wherein n is an integer from 1 to 2; R1 is selected from the group consisting of: (I) where Y is alkylene and R3 and R4 are the same or different and are selected from hydrogen, alkyl, or aryl, or R3 and R4 together form an alkylene chain having 4 to 5 carbon atoms optionally interrupted by a nitrogen or oxygen; (ii) pyridylalkyl; and (iii) piperidin-4-yl, optionally substituted phenyl; 2,2-diphenylethenyl; furanyl; carbozolyl. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute chronic pain, as antimanic depressants, as local as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.