Aethyl-decyl-sulfoxid | 24475-76-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 亚砜
• 英文名称: Aethyl-decyl-sulfoxid
• 英文别名: 1-Ethylsulfinyldecane
• CAS: 24475-76-1
• 化学式: C₁₂H₂₆OS
• 分子量: 218.404
• InChiKey: SXWXXYCJTDGKAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Transdermal treatment with mast cell degranulating agents for drug-induced hypersensitivity
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP0612525A1

  公开（公告）日：1994-08-31

  Methods and compositions for inhibiting or preventing the skin irritating or sensitizing effects of a skin irritating or sensitizing component of a dermal or transdermal drug delivery system are disclosed. The composition comprises a mast cell degranulating agent which is capable of inducing a state of immunological tolerance to the skin sensitizing agent by delivery prior to, or at the onset of transdermal drug delivery. Such an agent, preferably cis-urocanic acid or an analogue or metabolite thereof, can be administered before, during or after each transdermal drug delivery to achieve immune tolerance countersensitization. Alternatively, the agent can be used to induce countersensitization. The agent is preferably capable of permeating the epidermis and is administered transdermally. Novel methods and compositions comprising cis-urocanic acid or an analogue or metabolite thereof to obtain anti-inflammatory effects are also disclosed.

  本发明公开了用于抑制或预防皮肤或透皮给药系统中皮肤刺激性或致敏成分的皮肤刺激或致敏效应的方法和组合物。该组合物包含一种肥大细胞脱颗粒剂，它能够在透皮给药之前或开始时通过给药诱导对皮肤致敏剂的免疫耐受状态。可以在每次透皮给药之前、期间或之后给药这种药剂，最好是顺式尿囊酸或其类似物或代谢物，以达到免疫耐受反敏的目的。或者，也可以使用该药剂来诱导反敏。药剂最好能渗透表皮，并经皮肤给药。此外，还公开了包含顺式尿囊酸或其类似物或代谢物以获得抗炎效果的新方法和组合物。
• Transdermal acrylic multipolymer drug delivery system
  申请人：NOVEN PHARMACEUTICALS, INC.

  公开号：EP0379045B1

  公开（公告）日：1995-05-10
• SOLUBILITY PARAMETER BASED DRUG DELIVERY SYSTEM AND METHOD FOR ALTERING DRUG SATURATION CONCENTRATION
  申请人：NOVEN PHARMACEUTICALS, INC.

  公开号：EP0591432A1

  公开（公告）日：1994-04-13
• EP0591432A4
  申请人：——

  公开号：EP0591432A4

  公开（公告）日：1995-05-17
• METHOD AND APPARATUS FOR DIAGNOSING ERECTILE DYSFUNCTION
  申请人：Vivus, Inc.

  公开号：EP0754006A1

  公开（公告）日：1997-01-22