1-Azabicyclo<4.3.0>nonan-8,9-dion | 35620-54-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚里西啶
• 英文名称: 1-Azabicyclo<4.3.0>nonan-8,9-dion
• 英文别名: 8,9-Dioxo-1-azabicyclo<4.3.0>nonan；hexahydro-indolizine-2,3-dione；1,5,6,7,8,8a-Hexahydroindolizine-2,3-dione
• CAS: 35620-54-3
• 化学式: C₈H₁₁NO₂
• 分子量: 153.181
• InChiKey: QUIMDZPBNDDUCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Azabicyclo<4.3.0>nonan-8,9-dion 生成 2-hydroxy-6,7,8,8a,6',7',8',8'a-octahydro-5H,5'H-[1,2']biindolizinyl-3,3'-dione
  参考文献：
  名称：

  BENDER D. R.; BJELDANES L. F.; KNAPP D. R.; RAPOPORT H., J. ORG. CHEM. , 1975, 40, NO 9, 1264-1269

  摘要：

  DOI：

文献信息

• PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES
  申请人：Sankyo Company Limited

  公开号：EP1377577A1

  公开（公告）日：2004-01-07
• [EN] PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES<br/>[FR] DERIVES DE PYRROLE POUR TRAITER DES MALADIES DANS LESQUELLES INTERVIENNENT DES CYTOKINES
  申请人：SANKYO CO

  公开号：WO2002057264A1

  公开（公告）日：2002-07-25

  Compounds of formula (I): [wherein: A is a pyrrole ring; R1 is an optionally substituted aryl or heteroaryl group; R2 is an optionally substituted nitrogen-containing heteroaryl group; and R3 is formulae (IIa), (IIb) or (IIc), wherein m is 1 or 2, one of D and E is nitrogen and the other is ⊃C(R5)- (wherein R5 is hydrogen, a Substituent ≡ or a Substituent β), B is a nitrogen-containing 4- to 7-membered heterocyclic ring, and R4 is from 1 to 3 substituents from Substituent group ≡, substituent group β and Substituent group η; PROVIDED THAT R?1 and R3¿ are bonded to the two atoms of said pyrrole ring which are adjacent to the atom of the pyrrole ring to which said substituent R2 is bonded; Substituent group ≡ consists of hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio and halogeno alkythio groups and groups of formula NRaRb (wherein R?a and Rb¿ are hydrogen, alkyl, alkenyl, alkynyl, aralkyl and alkylsulfonyl, or R?a and Rb¿, taken together with the nitrogen atom to which they are attached, form a heterocyclyl); Substituent group β consists of optionally substituted alkyl, alkenyl and alkynyl groups, and aralkyl and cycloalkyl groups; Substituents group η consists of oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsufinyl, alkylsulfonyl, optionally substituted aryl, optionally substituted aryloxy, alkylidenyl and aralkylidenyl groups] have excellent activity against the production of inflammatory cytokines.