1-{1'-[4-(methylsulfonyl)phenyl]-4,4'-bipiperidin-1-yl}-1-oxooctan-2-one | 1034826-30-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-{1'-[4-(methylsulfonyl)phenyl]-4,4'-bipiperidin-1-yl}-1-oxooctan-2-one
• 英文别名: 1-[4-[1-(4-Methylsulfonylphenyl)piperidin-4-yl]piperidin-1-yl]octane-1,2-dione
• CAS: 1034826-30-6
• 化学式: C₂₅H₃₈N₂O₄S
• 分子量: 462.654
• InChiKey: QJLFHXRBOHAPMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  83.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Novel compositions for the delivery of negatively charged molecules
  申请人：Ribozyme Pharmaceuticals, Inc.

  公开号：US20030073640A1

  公开（公告）日：2003-04-17

  This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAs, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.

  本发明涉及一种透过性增强剂分子，及其方法，用于增加诸如核酸、多核酸、寡核酸、酶核酸分子、反义核酸分子、2-5A反义嵌合体、三链形成寡核酸、诱饵RNA、双链RNA、小干扰RNA、适配体或含有核酸切割化学基团的核酸、肽、多肽、蛋白质、碳水化合物、类固醇、金属和小分子等不同分子的膜透过性，从而促进细胞对这些分子的摄取。
• Novel Compositions for the Delivery of Negatively Charged Molecules
  申请人：Beigelman Leonid

  公开号：US20100036115A1

  公开（公告）日：2010-02-11

  This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAs, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.

  本发明涉及渗透增强分子及其方法，用于增加各种分子（如核酸、多核苷酸、寡核苷酸、酶性核酸分子、反义核酸分子、2-5A反义嵌合体、三链体形成寡核苷酸、诱骗RNA、双链RNA、小干扰RNA、适配体或含有核酸切割化学基团的反义核酸）的膜渗透性，以及肽、多肽、蛋白质、碳水化合物、类固醇、金属和小分子，从而促进这些分子的细胞摄取。
• ACYL BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：Wood Harold B.

  公开号：US20100075987A1

  公开（公告）日：2010-03-25

  Bipiperidyl compounds of the formula: (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

  公开了式子为(I)的双哌啶类化合物，用于治疗或预防2型糖尿病和类似疾病。同时包括药用可接受的盐和溶剂。这些化合物可作为G蛋白偶联受体GPR-119的激动剂。
• US6395713B1
  申请人：——

  公开号：US6395713B1

  公开（公告）日：2002-05-28
• US8399485B2
  申请人：——

  公开号：US8399485B2

  公开（公告）日：2013-03-19