11-hydroxy-8-methoxy-6-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one | 1285527-81-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 11-hydroxy-8-methoxy-6-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one
• CAS: 1285527-81-2
• 化学式: C₁₈H₁₅NO₃
• 分子量: 293.322
• InChiKey: AOJVYLKYQPFFIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.61
• 重原子数：
  22.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  51.46
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  11-hydroxy-8-methoxy-6-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one 在 重铬酸吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 8-Methoxy-6-methylindeno[1,2-c]isoquinoline-5,11-dione
  参考文献：
  名称：

  Suzuki–Miyaura cross-coupling and ring-closing metathesis: a strategic combination to the synthesis of indeno[1,2-c]isoquinolin-5,11-diones

  摘要：

  A variety of diversely substituted isoindeno[1,2-c]isoquinolin-5,11-diones has been readily assembled through a sequence involving a Suzuki-Miyaura cross-coupling reaction with enol phosphates combined with a ring-closing metathesis (RCM) reaction. Intramolecular carbocationic annulation reaction and ultimate oxidation of a latent hydroxyl functionality completed the synthesis of the target titled compounds. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.113
• 作为产物：
  描述：

  2-乙烯基苯甲酰氯 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 、 盐酸 、 双(三甲基硅烷基)氨基钾 、 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 丙酮 、 甲苯 为溶剂， 反应 38.33h， 生成 11-hydroxy-8-methoxy-6-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one
  参考文献：
  名称：

  Suzuki–Miyaura cross-coupling and ring-closing metathesis: a strategic combination to the synthesis of indeno[1,2-c]isoquinolin-5,11-diones

  摘要：

  A variety of diversely substituted isoindeno[1,2-c]isoquinolin-5,11-diones has been readily assembled through a sequence involving a Suzuki-Miyaura cross-coupling reaction with enol phosphates combined with a ring-closing metathesis (RCM) reaction. Intramolecular carbocationic annulation reaction and ultimate oxidation of a latent hydroxyl functionality completed the synthesis of the target titled compounds. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.113