N-(N'-methylpiperidin-4-yl)piperidine dihydrochloride | 5162-84-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(N'-methylpiperidin-4-yl)piperidine dihydrochloride
• 英文别名: 1-Methyl-4-piperidin-1-ylpiperidine;hydrochloride
• CAS: 5162-84-5
• 化学式: C₁₁H₂₂N₂*2ClH
• 分子量: 255.231
• InChiKey: RZGSBQPYJVLOQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.99
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  哌啶 、 N-甲基-4-哌啶酮 在 palladium on activated charcoal ammonium formate 作用下， 以 甲醇 、 水 为溶剂， 以68%的产率得到N-(N'-methylpiperidin-4-yl)piperidine dihydrochloride
  参考文献：
  名称：

  A modified palladium catalysed reductive amination procedure

  摘要：

  New, extended applications of a modified palladium catalysed reductive amination procedure are described; a mechanistic hypothesis alternative to the common imine pathway is proposed. This versatile method advances the usual reductive amination processes in terms of yield and shows high stereoselectivity whether applied to constrained carbonyl compounds. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00530-6

文献信息

• 1-GLYCINYL-4-(1-METHYLPIPERIDIN-4-YL)PIPERAZINES AND -PIPERIDINES AS FACTOR XA ANTAGONISTS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1409479A2

  公开（公告）日：2004-04-21
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSES CHIMIQUES
  申请人：LILLY CO ELI

  公开号：WO2003010160A2

  公开（公告）日：2003-02-06

  Compounds of formula (I) in which R?1, R2 and X4¿ have the me anings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
• A modified palladium catalysed reductive amination procedure
  作者：Valerio Berdini、Maria C Cesta、Roberto Curti、Gaetano D'Anniballe、Nicoletta Di Bello、Giuseppe Nano、Luca Nicolini、Alessandra Topai、Marcello Allegretti

  DOI：10.1016/s0040-4020(02)00530-6

  日期：2002.7

  New, extended applications of a modified palladium catalysed reductive amination procedure are described; a mechanistic hypothesis alternative to the common imine pathway is proposed. This versatile method advances the usual reductive amination processes in terms of yield and shows high stereoselectivity whether applied to constrained carbonyl compounds. (C) 2002 Elsevier Science Ltd. All rights reserved.