N-[5-(aminocarbonyl)-2-[4-(phenylmethyl)-1-piperidinyl]phenyl]hydrazinecarboxamide | 775349-77-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-[5-(aminocarbonyl)-2-[4-(phenylmethyl)-1-piperidinyl]phenyl]hydrazinecarboxamide
• 英文别名: 4-(4-Benzylpiperidin-1-yl)-3-(hydrazinecarbonylamino)benzamide
• CAS: 775349-77-4
• 化学式: C₂₀H₂₅N₅O₂
• 分子量: 367.451
• InChiKey: RHLGYRQONQWSMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  114
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Phospholipase C inhibitors for use in treating inflammatory disorders
  申请人：——

  公开号：US20040242639A1

  公开（公告）日：2004-12-02

  This invention is directed to heterocyclyl-substituted anilino phospholipase C inhibitor compounds useful in treating or ameliorating an inflammatory disorders and/or restenosis of the general formula (I): 1 and enantiomers, diastereomers and pharmaceutically acceptable salts thereof. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions affected by phospholipase modulation.

  本发明涉及一种杂环取代的苯胺磷脂酶C抑制剂化合物，其通式为(I)，可用于治疗或缓解炎症性疾病和/或一般公式(1)的再狭窄，包括对映体、非对映体和药学上可接受的盐。本发明还涉及包括本发明化合物的制药组合物以及治疗受磷脂酶调节影响的疾病的方法。
• [EN] PHOSPHOLIPASE C INHIBITORS FOR USE IN TREATING INFLAMMATORY DISORDERS<br/>[FR] INHIBITEURS DE PHOSPHOLIPASE C UTILISES DANS LE TRAITEMENT DE TROUBLES INFLAMMATOIRES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2004089901A2

  公开（公告）日：2004-10-21

  This invention is directed to heterocyclyl-substituted anilino phospholipase C inhibitor compounds useful in treating or ameliorating an inflammatory disorders and/or restenosis and enantiomers, diastereomers and pharmaceutically acceptable salts thereof. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions affected by phospholipase modulation.