N-phenyloxycarbonyl 4-hydroxypiperidine | 404338-64-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-phenyloxycarbonyl 4-hydroxypiperidine
• 英文别名: 1-Piperidinecarboxylic acid, 4-hydroxy-, phenyl ester；phenyl 4-hydroxypiperidine-1-carboxylate
• CAS: 404338-64-3
• 化学式: C₁₂H₁₅NO₃
• mdl: MFCD12472193
• 分子量: 221.256
• InChiKey: OFNUTURANYTHKC-UHFFFAOYSA-N

物化性质

• 沸点：
  364.1±42.0 °C(Predicted)
• 密度：
  1.245±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯基哌啶-1-羧酸酯 在 葡萄糖 、 cells of Sphingomonas sp. HXN-200 作用下， 以 phosphate buffer 为溶剂， 反应 4.0h， 以83.2%的产率得到N-phenyloxycarbonyl 4-hydroxypiperidine
  参考文献：
  名称：

  Practical Syntheses of N-Substituted 3-Hydroxyazetidines and 4-Hydroxypiperidines by Hydroxylation with Sphingomonas sp. HXN-200

  摘要：

  [GRAPHICS]Hydroxylation of N-substituted azetidines 11 and 12 and piperidines 15-19 with Sphingomonas sp. HXN-200 gave 91-98% of the corresponding 3-hydroxyazetidines 13 and 14 and 4-hydroxypiperidines 20-24, respectively, with high activity and excellent regioselectivity. High yields and high product concentrations (2 g/L) were achieved with frozen/thawed cells as biocatalyst. For the first time, rehydrated lyophilized cells were successfully used for the biohydroxylation.

  DOI：

  10.1021/ol025829s

文献信息

• Process for preparing n-substituted 4-hydroxypiperidines by enzymatic hudroxylation
  申请人：——

  公开号：US20040029237A1

  公开（公告）日：2004-02-12

  A process for the preparation of N-substituted 4-hydroxypiperidine, wherein an oxygen atom is inserted regioselectively into the corresponding N-substituted piperidine, by using as a biocatalyst a bacterium degrading alkanes or alicyclic hydrocarbons, or a prokaryotic host-organism having the gene(s) necessary for the hydroxylation derived from the said bacterium, or an enzyme having hydroxylation activity derived therefrom. The bacterium may be selected from species from, for example, the genera Sphingomonas and Pseudomonas, that are capable of degrading n-alkanes having 4 to 20 carbon atoms.

  一种制备N-取代4-羟基哌啶的方法，其中通过使用降解脂肪烃或脂环烃的细菌作为生物催化剂，或具有来自该细菌的羟化所需基因的原核生物宿主-有机体，或具有羟化活性的酶，将氧原子选择性地插入相应的N-取代哌啶中。细菌可以从Sphingomonas和Pseudomonas等属的物种中选择，这些物种能够降解具有4到20个碳原子的n-烷烃。
• Process for preparing N-substituted 4-hydroxypiperidines by enzymatic hydroxylation
  申请人：Eidgenössische Technische Hochschule Zürich

  公开号：EP1188837A1

  公开（公告）日：2002-03-20

  A process for the preparation of N-substituted 4-hydroxypiperidine, wherein an oxygen atom is inserted regioselectively into the corresponding N-substituted piperidine, by using as a biocatalyst a bacterium degrading alkanes or alicyclic hydrocarbons, or a prokaryotic host-organism having the gene(s) necessary for the hydroxylation derived from the said bacterium, or an enzyme having hydroxylation activity derived therefrom. The bacterium may be selected from species from, for example, the genera Sphingomonas and Pseudomonas, that are capable of degrading n-alkanes having 4 to 20 carbon atoms.

  一种制备 N-取代的 4-羟基哌啶的工艺，其中氧原子被选择性地插入到相应的 N-取代的哌啶中，制备方法是使用降解烷烃或脂环烃的细菌作为生物催化剂，或使用原核宿主生物，该宿主生物具有羟基化所需的基因，该基因来自上述细菌，或具有羟基化活性的酶，该酶来自上述细菌。该细菌可选自能够降解 4 至 20 个碳原子的正烷烃的鞘氨单胞菌属和假单胞菌属等菌种。
• Polarizing plate protective film, polarizing plate, liquid crystal display device, and production method of polarizing plate protective film
  申请人：FUJIFILM Corporation

  公开号：US10895775B2

  公开（公告）日：2021-01-19

  The invention is directed to a polarizing plate protective film containing a polymer having at least one of an ester bond and an amide bond and a compound which generates a base by an action of an acid, a polarizing plate including the polarizing plate protective film and a polarizer, a liquid crystal display device including a liquid crystal cell and the polarizing plate, and a production method of a polarizing plate protective film including producing the Polarizing plate protective film with a composition containing a polymer having at least one of an ester bond and an amide bond and a compound which generates a base by an action of an acid.

  本发明涉及一种偏光板保护膜，其中含有一种具有酯键和酰胺键中至少一种键的聚合物和一种在酸的作用下产生碱的化合物；一种偏光板，其中包括该偏光板保护膜和偏光板；一种液晶显示装置，其中包括液晶单元和该偏光板；以及一种偏光板保护膜的生产方法，其中包括用一种含有酯键和酰胺键中至少一种键的聚合物和一种在酸的作用下产生碱的化合物的组合物生产该偏光板保护膜。
• PROCESS FOR PREPARING N-SUBSTITUTED 4-HYDROXYPIPERIDINES BY ENZYMATIC HYDROXYLATION
  申请人：Eidgenössische Technische Hochschule Zürich

  公开号：EP1319085A1

  公开（公告）日：2003-06-18
• POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY DEVICE, AND PRODUCTION METHOD OF POLARIZING PLATE PROTECTIVE FILM
  申请人：FUJIFILM Corporation

  公开号：US20170090072A1

  公开（公告）日：2017-03-30

  The invention is directed to a polarizing plate protective film containing a polymer having at least one of an ester bond and an amide bond and a compound which generates a base by an action of an acid, a polarizing plate including the polarizing plate protective film and a polarizer, a liquid crystal display device including a liquid crystal cell and the polarizing plate, and a production method of a polarizing plate protective film including producing the Polarizing plate protective film with a composition containing a polymer having at least one of an ester bond and an amide bond and a compound which generates a base by an action of an acid.