N-Acetyl-4,5-dimethyl-hexahydroazepin | 41225-20-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-Acetyl-4,5-dimethyl-hexahydroazepin
• 英文别名: 1-(4,5-Dimethylazepan-1-yl)ethanone
• CAS: 41225-20-1
• 化学式: C₁₀H₁₉NO
• 分子量: 169.267
• InChiKey: ALIUMSBFXDYTHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Histone Deacetylase Inhibitors and Methods of Use Thereof
  申请人：Reaction Biology Corp.

  公开号：US20190270744A1

  公开（公告）日：2019-09-05

  The present invention relates to methods of modulating activity of histone deacetylases (HDACs). The present invention also relates to methods of treating HDAC-associated diseases including, but not limited to, cancers, inflammatory disorders, and neurodegenerative disorders. The present invention also provides novel compounds and compositions thereof and methods of preparation of the same. The present invention also includes methods of inhibiting HDACs, and methods of treating HDAC-associated diseases using the compounds of the invention.

  本发明涉及调节组蛋白去乙酰化酶（HDACs）活性的方法。本发明还涉及治疗与HDAC相关的疾病的方法，包括但不限于癌症、炎症性疾病和神经退行性疾病。本发明还提供了新型化合物及其组合物和制备方法。本发明还包括抑制HDACs的方法，以及使用本发明的化合物治疗HDAC相关疾病的方法。
• Histone deacetylase inhibitors and methods of use thereof
  申请人：Reaction Biology Corp.

  公开号：US11155550B2

  公开（公告）日：2021-10-26

  The present invention relates to methods of modulating activity of histone deacetylases (HDACs). The present invention also relates to methods of treating HDAC-associated diseases including, but not limited to, cancers, inflammatory disorders, and neurodegenerative disorders. The present invention also provides novel compounds and compositions thereof and methods of preparation of the same. The present invention also includes methods of inhibiting HDACs, and methods of treating HDAC-associated diseases using the compounds of the invention.

  本发明涉及调节组蛋白去乙酰化酶（HDAC）活性的方法。本发明还涉及治疗 HDAC 相关疾病的方法，这些疾病包括但不限于癌症、炎症性疾病和神经退行性疾病。本发明还提供了新型化合物及其组合物以及制备方法。本发明还包括抑制 HDAC 的方法，以及使用本发明化合物治疗 HDAC 相关疾病的方法。