3-benzyl-7-[3-(4-cyanophenoxy)-2-hydroxypropyl]-6-methyl-3,7-diazabicyclo[3.3.1]nonane | 1100805-16-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-benzyl-7-[3-(4-cyanophenoxy)-2-hydroxypropyl]-6-methyl-3,7-diazabicyclo[3.3.1]nonane
• 英文别名: 4-[3-(7-Benzyl-2-methyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)-2-hydroxypropoxy]benzonitrile
• CAS: 1100805-16-0
• 化学式: C₂₅H₃₁N₃O₂
• 分子量: 405.54
• InChiKey: SEOQYNBBMGIYOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  59.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• New bispidine compounds and their use in the treatment of cardiac arrhythmias
  申请人：——

  公开号：US20030212095A1

  公开（公告）日：2003-11-13

  There is provided compounds of formula (I), wherein R 1 , R 2 , R 3a , R 3b and R 41 to R 46 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias. 1

  提供了化合物的结构式(I)，其中R1、R2、R3a、R3b和R41至R46的含义如描述中所示，这些化合物在预防和治疗心律失常方面具有用途，特别是房性和室性心律失常。
• New bispidine compounds useful in the treatment of cardiac arrhythmias
  申请人：Bjorsne Magnus

  公开号：US20050004113A1

  公开（公告）日：2005-01-06

  There is provided compounds of formula I, wherein R 1 , R 2 , R 3 , R 4 , R 5a , R 5b , R 5c , R 5d , R 5e , R 5f , R 6 , X, A, B and D have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

  提供了式I的化合物，其中R1、R2、R3、R4、R5a、R5b、R5c、R5d、R5e、R5f、R6、X、A、B和D的含义如描述中所述，这些化合物在预防和治疗心律失常方面有用，特别是房性和室性心律失常。
• BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS
  申请人：AstraZeneca AB

  公开号：EP1192156B1

  公开（公告）日：2004-02-18
• [EN] NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS<br/>[FR] COMPOSES DE BISPIDINE POUVANT ETRE UTILISES POUR LE TRAITEMENT DE L'ARYTHMIE CARDIAQUE
  申请人：ASTRAZENECA AB

  公开号：WO2000076998A1

  公开（公告）日：2000-12-21

  There is provided compounds of formula (I), wherein R?1, R2, R3, R4, R5a, R5b, R5c, R5d, R5e, R5f, R6¿, X, A, B and D have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.