2-chloro-4-(1'-pyrimidin-2-yl-4,4'-bipiperidin-1-yl)benzonitrile | 1039742-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-chloro-4-(1'-pyrimidin-2-yl-4,4'-bipiperidin-1-yl)benzonitrile
• 英文别名: 2-Chloro-4-[4-(1-pyrimidin-2-ylpiperidin-4-yl)piperidin-1-yl]benzonitrile
• CAS: 1039742-48-7
• 化学式: C₂₁H₂₄ClN₅
• 分子量: 381.908
• InChiKey: OODYHXNPQHPKSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  56
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：Wood Harold B.

  公开号：US20100029688A1

  公开（公告）日：2010-02-04

  Bipiperidinyl compounds of the formula I, are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

  公开了式I的双哌啶化合物，可用于治疗或预防2型糖尿病和类似疾病。药学上可接受的盐和溶剂也包括在内。这些化合物是G蛋白偶联受体GPR-119的激动剂。
• SOLUBLE EPOXIDE HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：Yang Cangming

  公开号：US20110039860A1

  公开（公告）日：2011-02-17

  Compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof is disclosed. The compounds are useful for treating diabetes, inflammation, atherosclerosis, hypertension, pain and the like. Pharmaceutical compositions and methods of use are also included.

  本发明揭示了式(I)的化合物或其药学上可接受的盐或溶剂。这些化合物可用于治疗糖尿病、炎症、动脉硬化、高血压、疼痛等。此外，还包括制药组合物和使用方法。
• BIPIPERIDINYL COMPOUNDS, COMPOSITIONS, CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：WOOD HAROLD B.

  公开号：US20120178681A1

  公开（公告）日：2012-07-12

  Bipiperidinyl compounds of the formula I, are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

  公开了式I的双哌啶化合物，可用于治疗或预防2型糖尿病和类似疾病。药学上可接受的盐和溶剂也包括在内。这些化合物可用作G蛋白偶联受体GPR-119的激动剂。
• US8445499B2
  申请人：——

  公开号：US8445499B2

  公开（公告）日：2013-05-21
• US8455520B2
  申请人：——

  公开号：US8455520B2

  公开（公告）日：2013-06-04