2-(4-morpholin-4-yl-piperidin-1-yl)-ethylamine | 1067659-27-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-(4-morpholin-4-yl-piperidin-1-yl)-ethylamine
• 英文别名: 2-(4-Morpholinopiperidin-1-yl)ethan-1-amine；2-(4-morpholin-4-ylpiperidin-1-yl)ethanamine
• CAS: 1067659-27-1
• 化学式: C₁₁H₂₃N₃O
• 分子量: 213.323
• InChiKey: YWWRAYRVWALOBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  41.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases
  申请人：Boettcher Andreas

  公开号：US20100125064A1

  公开（公告）日：2010-05-20

  The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula I, wherein R 1 , R 2 , R 3 , R 4 , R A , Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.

  本发明涉及能够抑制p53或其变体与MDM2和/或MDM4或其变体相互作用的3-杂环基吲哚化合物，其中所述化合物具有式I，其中R1、R2、R3、R4、RA、Y和Y的定义见说明书。由于其活性，这些化合物可用于治疗由MDM2和/或MDM4或其变体介导的各种疾病和疾病，例如炎症性或增殖性疾病或细胞保护。
• 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES
  申请人：Novartis AG

  公开号：EP2142535A2

  公开（公告）日：2010-01-13
• US8053457B2
  申请人：——

  公开号：US8053457B2

  公开（公告）日：2011-11-08
• [EN] 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES<br/>[FR] 3-IMIDAZOLYL-INDOLES POUR LE TRAITEMENT DE MALADIES PROLIFÉRATIVES
  申请人：NOVARTIS AG

  公开号：WO2008119741A2

  公开（公告）日：2008-10-09

  [EN] The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula (I) wherein R¹, R², R³, R⁴, R^A, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.
  [FR] L'invention porte sur des composés 3-hétérocyclyl indolylés, capables d'inhiber l'interaction entre p53, ou des variantes de celui-ci, et MDM2 et/ou MDM4, ou des variantes de ceux-ci, respectivement, lesdits composés ayant la formule (I) dans laquelle R¹, R², R³, R⁴, R^A, Y et Y sont tels que définis dans la description. En raison de leur activité, les composés sont utiles dans le traitement de divers troubles et diverses maladies à médiation par l'activité de MDM2 et/ou MDM4, ou des variantes de ceux-ci, tels que des maladies inflammatoires ou prolifératives ou dans la protection de cellules.