Nicotinamide-adenine-dinucleotide phosphate | 604-79-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - （5'->5'）-二核苷酸
• 英文名称: Nicotinamide-adenine-dinucleotide phosphate
• 英文别名: NADP+；NADP；Nicotinamid-adenin-dinucleotidphosphat, NADP+；[[5-(6-Aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
• CAS: 604-79-5
• 化学式: C₂₁H₂₉N₇O₁₇P₃
• 分子量: 744.419
• InChiKey: XJLXINKUBYWONI-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -7
• 重原子数：
  48
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  365
• 氢给体数：
  9
• 氢受体数：
  21

反应信息

• 作为反应物：
  描述：

  Nicotinamide-adenine-dinucleotide phosphate 、 glucose 6-phosphate 、 乙二醇单十二烷基醚 、 二甲基亚砜 以 三羟甲基氨基甲烷 为溶剂， 反应 2.67h， 生成 还原型辅酶II(NADPH)四钠盐
  参考文献：
  名称：

  COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES

  摘要：

  本发明涉及公式I的化合物或其药学上可接受的盐，其与葡萄糖激酶调节蛋白相互作用。此外，本发明涉及使用这些化合物或其药学上可接受的盐以及含有这些化合物或其药学上可接受的盐的药物组合物治疗2型糖尿病以及其他与葡萄糖激酶调节蛋白有关的疾病和/或病况的方法。

  公开号：

  US20120225854A1

文献信息

• Method for enumeration of mammalian cell micronuclei, while distinguishing chromatin of dead and dying cells
  申请人：Litron Laboratories, Ltd.

  公开号：US10000793B2

  公开（公告）日：2018-06-19

  The present invention relates a method for the enumeration of mammalian cell micronuclei, while distinguishing micronuclei from the chromatin of dead and dying cells. The method utilizes differential staining of chromatin from dead and dying cells, to distinguish the chromatin from micronuclei and nuclei that can be detected based upon fluorescent emission and light scatter following exposure to an excitatory light source. Counting of micronuclei events relative to the number of nuclei can be used to assess the DNA-damaging potential of a chemical agent, the DNA-damaging potential of a physical agent, the effects of an agent which can modify endogenously-induced DNA damage, and the effects of an agent which can modify exogenously-induced DNA damage. Kits for practicing the invention are also disclosed.

  本发明涉及一种枚举哺乳动物细胞微核的方法，同时将微核与死亡和濒死细胞的染色质区分开来。该方法利用对死亡和濒死细胞染色质的不同染色，将染色质与微核和细胞核区分开来，微核和细胞核在暴露于激发光源后可根据荧光发射和光散射进行检测。相对于细胞核数量的微核事件计数可用于评估化学制剂的 DNA 损伤潜能、物理制剂的 DNA 损伤潜能、可改变内源性 DNA 损伤的制剂的效果以及可改变外源性 DNA 损伤的制剂的效果。还公开了用于实施本发明的试剂盒。
• Method for enumerating mammalian cell micronuclei with an emphasis on differentially staining micronuclei and the chromatin of dead and dying cells
  申请人：Dertinger D. Stephen

  公开号：US20060040291A1

  公开（公告）日：2006-02-23

  The present invention relates a method for the enumeration of mammalian cell micronuclei, while distinguishing micronuclei from the chromatin of dead and dying cells. The method utilizes differential staining of chromatin from dead and dying cells, to distinguish the chromatin from micronuclei and nuclei that can be detected based upon fluorescent emission and light scatter following exposure to an excitatory light source. Counting of micronuclei events relative to the number of nuclei can be used to assess the DNA-damaging potential of a chemical agent, the DNA-damaging potential of a physical agent, the effects of an agent which can modify endogenously-induced DNA damage, and the effects of an agent which can modify exogenously-induced DNA damage. Kits for practicing the invention are also disclosed.

  本发明涉及一种枚举哺乳动物细胞微核的方法，同时将微核与死亡和濒死细胞的染色质区分开来。该方法利用对死亡和濒死细胞染色质的不同染色，将染色质与微核和细胞核区分开来，微核和细胞核在暴露于激发光源后可根据荧光发射和光散射进行检测。相对于细胞核数量的微核事件计数可用于评估化学制剂的 DNA 损伤潜能、物理制剂的 DNA 损伤潜能、可改变内源性 DNA 损伤的制剂的效果以及可改变外源性 DNA 损伤的制剂的效果。还公开了用于实施本发明的试剂盒。
• METHOD FOR ENUMERATING MAMMALIAN CELL MICRONUCLEI WITH AN EMPHASIS ON DIFFERENTIALLY STAINING MICRONUCLEI AND THE CHROMATIN OF DEAD AND DYING CELLS
  申请人：Litron Laboratories Ltd.

  公开号：EP1769081A2

  公开（公告）日：2007-04-04
• EP1769081A4
  申请人：——

  公开号：EP1769081A4

  公开（公告）日：2008-04-16
• KIT FOR ENUMERATING MAMMALIAN CELL MICRONUCLEI WITH AN EMPHASIS ON DIFFERENTIALLY STAINING MICRONUCLEI AND THE CHROMATIN OF DEAD AND DYING CELLS
  申请人：Dertinger Stephen D.

  公开号：US20090029386A1

  公开（公告）日：2009-01-29

  The present invention relates a method for the enumeration of mammalian cell micronuclei, while distinguishing micronuclei from the chromatin of dead and dying cells. The method utilizes differential staining of chromatin from dead and dying cells, to distinguish the chromatin from micronuclei and nuclei that can be detected based upon fluorescent emission and light scatter following exposure to an excitatory light source. Counting of micronuclei events relative to the number of nuclei can be used to assess the DNA-damaging potential of a chemical agent, the DNA-damaging potential of a physical agent, the effects of an agent which can modify endogenously-induced DNA damage, and the effects of an agent which can modify exogenously-induced DNA damage. Kits for practicing the invention are also disclosed.