(E)-3-(piperidin-1-yl)acrylamide | 64164-01-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (E)-3-(piperidin-1-yl)acrylamide
• 英文别名: (E)-3-piperidin-1-ylprop-2-enamide
• CAS: 64164-01-8
• 化学式: C₈H₁₄N₂O
• 分子量: 154.212
• InChiKey: FDXQYYOWBYEVGB-QPJJXVBHSA-N

物化性质

• 熔点：
  143-144 °C
• 沸点：
  321.2±25.0 °C(Predicted)
• 密度：
  1.149±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-3-(piperidin-1-yl)acrylamide 、 丁炔二酸二甲酯 以23%的产率得到
  参考文献：
  名称：

  NUVOLE, ANTONIO;PAGLIETTI, GIUSEPPE, J. CHEM. SOC. PERKIN TRANS. PT 1,(1989) N, C. 1007-1011

  摘要：

  DOI：
• 作为产物：
  描述：

  哌啶 、 丙炔酰胺 以 乙醚 为溶剂， 反应 1.0h， 以91%的产率得到(E)-3-(piperidin-1-yl)acrylamide
  参考文献：
  名称：

  （E）-β-烯胺酰胺与乙酰二羧酸二甲酯（DMAD）的反应：苯衍生物，烯胺酯和2-吡啶酮的形成

  摘要：

  （的加法调查ë）-enamino酰胺（1A - d）与DMAD已经表明，它们是由中间体的立体化学和烯胺系统的胺成分的影响。在干乙腈中，（E）-苄基（甲基）氨基-（1b），（E）-吡咯烷-1-基氨基-（1c）和（E）-哌啶-1-基氨基-（1d）丙烯酰胺，得到四甲基苯-1,2,3,4-四羧酸酯（5），（E）-氨基丁烯二酸酯（6b - d）和3,4-双甲氧基羰基吡啶-2-（1 H）-一8）。由于β-碳的不同亲核性，二甲氨基-（1a）和吗啉-1-基氨基-（1e）-丙烯酰胺形成了两性离子（11），该两性离子消除了丙醇酰胺，仅得到（E）-氨基丁烯二酸酯（6a，e）。

  DOI：

  10.1039/p19890001007

文献信息

• [EN] INHIBITORS OF BRUTON'S TYROSINE KINASE<br/>[FR] INHIBITEURS DE LA TYROSINE KINASE DE BRUTON
  申请人：PHARMACYCLICS LLC

  公开号：WO2016004272A1

  公开（公告）日：2016-01-07

  Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

  本文披露了抑制布鲁顿酪氨酸激酶（Btk）的化合物。还描述了Btk的不可逆抑制剂。此外，还描述了Btk的可逆抑制剂。还披露了包括这些化合物的药物组合物。披露了使用Btk抑制剂的方法，单独或与其他治疗剂联合治疗自身免疫疾病或症状、异源免疫疾病或症状、癌症（包括淋巴瘤）和炎症性疾病或症状。
• PROCESS FOR PRODUCING PARTICULATE POLYMER
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0406432A1

  公开（公告）日：1991-01-09

  The invention provides a process for producing particulate polymer, which comprises polymerizing either one or more of N-alkyl- or N-alkylene-substituted (meth)acrylamides or a mixture of said one or more of N-alkyl- or N-alkylene-substituted (meth)acrylamides with other copolymerizable monomer(s) dispersed in an aqueous solution of an inorganic salt containing inorganic particles suspended therein. This process provides particulate polymer not containing such impurities as a polymer stabilizer or a surfactant. This polymer is useful as a concentrating agent, a base for sustained release, and the like.

  本发明提供了一种生产微粒聚合物的工艺，该工艺包括聚合一种或多种 N-烷基或 N-亚烷基取代的（甲基）丙烯酰胺，或上述一种或多种 N-烷基或 N-亚烷基取代的（甲基）丙烯酰胺与其他可共聚单体的混合物，这些单体分散在无机盐水溶液中，其中含有悬浮的无机微粒。这种工艺可提供不含聚合物稳定剂或表面活性剂等杂质的微粒聚合物。这种聚合物可用作浓缩剂、缓释基质等。
• Use of water-soluble polymers in cleaning compositions, and water-soluble polymers for such use
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0560519A2

  公开（公告）日：1993-09-15

  The invention provides a method of enhancing the filming and spotting characteristics of cleaning compositions, for example hard surface cleaners and automatic machine dishwashing formulations, by incorporating into the compositions polymers containing, as polymerized units, (a) one or more monomer selected from C3-C6 monoethylenically unsaturated carboxylic acids and alkali metal and ammonium salts thereof, (b) one or more an-aminoacryloyl derivative, and (c) optionally, one or more monoethylenically unsaturated monomer polymerisable with (a) and (b). The invention also provides polymers suitable for use in such method.

  本发明提供了一种增强清洁组合物（例如硬表面清洁剂和自动洗碗机配方）的成膜和斑点特性的方法，其方法是在组合物中加入含有以下聚合单元的聚合物、(a) 一种或多种选自 C3-C6 单乙烯基不饱和羧酸及其碱金属盐和铵盐的单体， (b) 一种或多种氨基丙烯酰衍生物，以及 (c) 可与 (a) 和 (b) 聚合的一种或多种单乙烯基不饱和单体。本发明还提供了适用于这种方法的聚合物。
• POWDER PAINT, METHOD OF MANUFACTURING THE SAME, AND METHOD OF PAINTING USING THE PAINT
  申请人：NIPPON CARBIDE KOGYO KABUSHIKI KAISHA

  公开号：EP0751192A1

  公开（公告）日：1997-01-02

  The present invention provides a powder coating comprising associated particles having an average particle diameter of 3-70 µm, said associated particles containing fine polymer particles having an average particle diameter of 0.01-2 µm. The powder coating of the present invention comprises powder coating particles which have a relatively narrow particle size distribution, which have a relatively small average particle diameter, and which are controlled in shape. Moreover, the powder coating can be produced at a high yield, is greatly superior in fluidity and electrifiability as compared with conventional powder coatings; gives a coating film having excellent luster and sufficient smoothness; and can be applied in a thin film.

  本发明提供了一种粉末涂料，包括平均颗粒直径为 3-70 微米的相关颗粒，所述相关颗粒包含平均颗粒直径为 0.01-2 微米的细聚合物颗粒。 本发明的粉末涂料包含粒径分布相对较窄、平均粒径相对较小且形状可控的粉末涂料颗粒。此外，本发明的粉末涂料产量高，与传统的粉末涂料相比，流动性和可电性大大提高，涂膜具有极佳的光泽和足够的平滑度，并且可以薄膜涂覆。
• CONDUCTIVE ROLLER
  申请人：TOKAI RUBBER INDUSTRIES, LTD.

  公开号：EP0982335A1

  公开（公告）日：2000-03-01

  A conductive roll to be used as a developing roll, a charging roll, a transfer roll or the like in an electrophotographic apparatus such as a copying machine, a printer or a facsimile, of the present invention comprises a base rubber layer formed on a peripheral surface of a shaft, an intermediate layer formed on a peripheral surface of the base rubber layer, and a surface layer formed on a peripheral surface of the intermediate layer, the surface layer being composed of a resin composition comprising: (A) a silicone-grafted acrylic polymer which comprises repeating units represented by the following general formula (1), wherein an acrylic polymer portion of the silicone-grafted acrylic polymer exclusive of a structural portion derived from a siloxane has a glass-transition temperature of -35 to 30°C:-(Y)k- -(Z)n- (wherein Y is a structural portion derived from an acrylic monomer; Z is a structural portion derived from the acrylic monomer, which has a graft portion derived from a siloxane; k is a positive number of 1 to 3,000; and n is a positive number of 1 to 3,000); and (B) an isocyanate curing agent. According to the present invention, the use of the component (B) enhances the cross-linking of the silicone-component (B) enhances the cross-linking of the silicone-grafted acrylic polymer (A), and thus the surface layer of the conductive roll has an appropriately cross-linked state, so that the conductive roll can be obtained which is superior both in smear resistance and in toner filming resistance.

  本发明的导电辊可用作复印机、打印机或传真机等电子照相设备中的显影辊、充电辊、转印辊或类似设备，它包括形成在轴外周表面上的基体橡胶层、形成在基体橡胶层外周表面上的中间层以及形成在中间层外周表面上的表层，表层由树脂组合物构成，树脂组合物包括： (A) 有机硅接枝的丙烯酸聚合物，该聚合物由以下通式(1)表示的重复单元组成，其中有机硅接枝丙烯酸聚合物的丙烯酸聚合物部分（不包括硅氧烷衍生的结构部分）的玻璃化转变温度为-35 至 30°C：-(Y)k--(Z)n-(其中 Y 是源自丙烯酸单体的结构部分；Z 是源自丙烯酸单体的结构部分，该丙烯酸单体具有源自硅氧烷的接枝部分；k 是 1 至 3,000 的正数；n 是 1 至 3,000 的正数)；以及 (B) 异氰酸酯固化剂。 根据本发明，使用组分（B）可增强有机硅组分（B）的交联，增强有机硅接枝丙烯酸聚合物（A）的交联，从而使导电辊的表层具有适当的交联状态，这样就可以获得抗涂抹性和抗墨粉成膜性都很出色的导电辊。