1-(4-methyl-5-(1-phenylcyclopropyl)-4H-1,2,4-triazol-3-yl)piperidin-4-ol | 851766-98-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(4-methyl-5-(1-phenylcyclopropyl)-4H-1,2,4-triazol-3-yl)piperidin-4-ol
• 英文别名: 1-[4-Methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]piperidin-4-ol
• CAS: 851766-98-8
• 化学式: C₁₇H₂₂N₄O
• 分子量: 298.388
• InChiKey: PQWNLSXONLEYGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  54.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Heterocyclic inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1 and methods of using the same
  申请人：Li Yun-Long

  公开号：US20070270424A1

  公开（公告）日：2007-11-22

  The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1.

  本发明涉及11-β羟基类固醇脱氢酶1型的抑制剂及其制药组合物。本发明的化合物可用于治疗与11-β羟基类固醇脱氢酶1型的表达或活性有关的各种疾病。
• HETEROCYCLIC INHIBITORS OF 11-B HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME
  申请人：Incyte Corporation

  公开号：EP2018378A2

  公开（公告）日：2009-01-28
• Triazole Compounds and Uses Related Thereto
  申请人：Powers Jay P.

  公开号：US20080249084A1

  公开（公告）日：2008-10-09

  The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound is useful as a therapeutic drug for the treatment of diabetes, obesity or metabolic syndrome.
• TRIAZOLE COMPOUNDS AND USES RELATED THERETO
  申请人：POWERS JAY P.

  公开号：US20100062972A1

  公开（公告）日：2010-03-11

  The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound has superior HSD1 inhibitory activity, and is useful as an HSD1 inhibitor, a therapeutic drug of diabetes or a therapeutic drug of obesity or a therapeutic drug of metabolic syndrome.
• US7683059B2
  申请人：——

  公开号：US7683059B2

  公开（公告）日：2010-03-23