5-(1-Trityl-1H-imidazol-4-yl)-pentylamine | 214283-56-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5-(1-Trityl-1H-imidazol-4-yl)-pentylamine
• CAS: 214283-56-4
• 化学式: C₂₇H₂₉N₃
• 分子量: 395.547
• InChiKey: MBWGQHQMSIRIQM-UHFFFAOYSA-N

物化性质

• 沸点：
  555.5±38.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.39
• 重原子数：
  30.0
• 可旋转键数：
  9.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  43.84
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  5-(1-Trityl-1H-imidazol-4-yl)-pentylamine 在 盐酸 、 三乙胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 24.0h， 生成 N-[5-(1H-Imidazol-4-yl)-pentyl]-4-trifluoromethoxy-benzenesulfonamide; hydrochloride
  参考文献：
  名称：

  Novel H3 receptor antagonists. Sulfonamide homologs of histamine

  摘要：

  Sulfonamides derived from 4(5)-(omega-aminoalkyl)-1H-imidazoles containing chain lengths of three- to five-carbons were synthesized. Good to moderate H-3 receptor binding affinities were observed for several butyl and pentyl homologs, whereas binding affinities were considerably weaker in the propyl series. Separation of the imidazole ring and the sulfonamide unit by a four- or five-carbon tether afforded potent H-3 receptor antagonists. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00379-5
• 作为产物：
  描述：

  2-[5-(1-trityl-1H-imidazol-4-yl)pentyl]isoindole-1,3-dione 在 肼 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以92%的产率得到5-(1-Trityl-1H-imidazol-4-yl)-pentylamine
  参考文献：
  名称：

  Novel H3 receptor antagonists. Sulfonamide homologs of histamine

  摘要：

  Sulfonamides derived from 4(5)-(omega-aminoalkyl)-1H-imidazoles containing chain lengths of three- to five-carbons were synthesized. Good to moderate H-3 receptor binding affinities were observed for several butyl and pentyl homologs, whereas binding affinities were considerably weaker in the propyl series. Separation of the imidazole ring and the sulfonamide unit by a four- or five-carbon tether afforded potent H-3 receptor antagonists. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00379-5