1-(4-Aminomethyl-3-fluoro-phenyl)cyclopropanol | 353283-42-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(4-Aminomethyl-3-fluoro-phenyl)cyclopropanol
• 英文别名: 1-[4-(Aminomethyl)-3-fluorophenyl]cyclopropan-1-ol
• CAS: 353283-42-8
• 化学式: C₁₀H₁₂FNO
• 分子量: 181.21
• InChiKey: KPPUTYBCMMVJMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of pde4 isozymes
  申请人：——

  公开号：US20030186989A1

  公开（公告）日：2003-10-02

  Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructive pulmonary disease, of Formula (1.0.0): 1 wherein R 5 and R 6 are taken together to form a moiety of partial Formulas (1.1.1) through (1.1.5): 2 or a pharmaceutically acceptable salt thereof.

  在治疗由嗜酸性粒细胞的激活和脱颗粒调节的疾病，特别是哮喘、慢性支气管炎和慢性阻塞性肺病中作为PDE4抑制剂有用的化合物，其化学式为（1.0.0）： 其中R5和R6一起取代形成部分化学式（1.1.1）至（1.1.5）的基团， 或其药用可接受的盐。
• NICOTINAMIDE BENZOFUSED-HETEROCYCLYL DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF PDE4 ISOZYMES
  申请人：Pfizer Products Inc.

  公开号：EP1252158A1

  公开（公告）日：2002-10-30
• US7354941B2
  申请人：——

  公开号：US7354941B2

  公开（公告）日：2008-04-08
• [EN] NICOTINAMIDE BENZOFUSED-HETEROCYCLYL DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF PDE4 ISOZYMES<br/>[FR] DERIVES BENZOCONDENSES HETEROCYCLIQUES DE NICOTINAMIDE UTILES COMME INHIBITEURS SELECTIFS D'ISOZYMES PDE4
  申请人：PFIZER PROD INC

  公开号：WO2001057036A1

  公开（公告）日：2001-08-09

  Compounds useful as inhibitors of PDE4 in the treatment of diseas s regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructive pulmonary disease, of Formula (1.0.0.). In said formula R?5 and R6¿ are taken together to form a moiety of partial Formulas (1.1.1) through (1.1.5) or a pharmaceutically acceptable salt thereof.