4-O-monomethoxytrityl-N-(thymine-1-ylacetyl)-L-hydroxyproline | 261517-65-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 4-O-monomethoxytrityl-N-(thymine-1-ylacetyl)-L-hydroxyproline
• 英文别名: 4-(4-methoxytrityloxy)-N-[(thymin-1-yl)acetyl]-L-proline；(2S,4R)-4-[(4-methoxyphenyl)-diphenylmethoxy]-1-[2-(5-methyl-2,4-dioxopyrimidin-1-yl)acetyl]pyrrolidine-2-carboxylic acid
• CAS: 261517-65-1
• 化学式: C₃₂H₃₁N₃O₇
• 分子量: 569.614
• InChiKey: GZCNPANAZOKDDM-SXOMAYOGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  42
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-O-monomethoxytrityl-N-(thymine-1-ylacetyl)-L-hydroxyproline 在 ammonium hydroxide 、 二苯基磷酸 、 三乙胺 作用下， 以 乙腈 为溶剂， 生成 C₄₁H₄₉N₆O₇P
  参考文献：
  名称：

  Novel Oligonucleotide Analogues Derived From Serine and 4-Hydroxyproline

  摘要：

  A set of DNA analogues derived from serine and 4-hydroxyproline and containing carboxamidomethyl phosphonate and carboxamidophosphate bonds between monomeric units was synthesized.

  DOI：

  10.1080/07328319908044741
• 作为产物：
  描述：

  胸腺嘧啶-1-乙酸 在 N,N-二异丙基乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 吡啶 为溶剂， 生成 4-O-monomethoxytrityl-N-(thymine-1-ylacetyl)-L-hydroxyproline
  参考文献：
  名称：

  Novel Oligonucleotide Analogues Derived From Serine and 4-Hydroxyproline

  摘要：

  A set of DNA analogues derived from serine and 4-hydroxyproline and containing carboxamidomethyl phosphonate and carboxamidophosphate bonds between monomeric units was synthesized.

  DOI：

  10.1080/07328319908044741

文献信息

• Polyester and N-Methyl Analogues of Peptide Nucleic Acids: Synthesis and Hybridization Properties
  作者：V. A. Efimov、A. A. Buryakova、M. V. Choob、O. G. Chakhmakhcheva

  DOI：10.1080/07328319908044625

  日期：1999.11

  The synthesis of a set of homo-thymine analogues of peptide nucleic acids containing ester or N-methylamide linkages as well as analogues derived from trans-4-hydroxy-L-proline and their hybrids has been accomplished, and their binding affinity to complementary DNA and RNA strands was evaluated.
• Efimov; Buryakova; Choob, Russian Journal of Bioorganic Chemistry, 1999, vol. 25, # 8, p. 545 - 555
  作者：Efimov、Buryakova、Choob、Chakhmakhcheva

  DOI：——

  日期：——