[2-nitro-4-(piperidylmethyl)phenyl]-methylamine | 630410-47-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [2-nitro-4-(piperidylmethyl)phenyl]-methylamine
• 英文别名: [2-Nitro-4-(piperidin-1-ylmethyl)phenyl]methanamine
• CAS: 630410-47-8
• 化学式: C₁₃H₁₉N₃O₂
• 分子量: 249.313
• InChiKey: JNMHWPHLNLWJJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  75.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use
  申请人：——

  公开号：US20030229068A1

  公开（公告）日：2003-12-11

  Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的化合物对于治疗疾病，如细胞增殖或凋亡介导的疾病，具有有效性。该发明涵盖了新颖的化合物、类似物、前药和其药学上可接受的衍生物，药物组合物以及预防和治疗涉及中风、癌症等疾病和其他疾病或病症的方法。该发明还涉及制备这些化合物的方法，以及在这些方法中有用的中间体。
• 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS
  申请人：AMGEN INC.

  公开号：EP1507776B1

  公开（公告）日：2007-02-28
• US7119111B2
  申请人：——

  公开号：US7119111B2

  公开（公告）日：2006-10-10
• [EN] 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS<br/>[FR] DERIVES 2-OXO-1,3,4-TRIHYDROQUINAZOLINYLE UTILISES DANS LE TRAITEMENT DE TROUBLES ASSOCIES A LA PROLIFERATION DE CELLULES
  申请人：AMGEN INC

  公开号：WO2003101985A1

  公开（公告）日：2003-12-11

  Compounds of formula (I) are effective for treatment of cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.