nBuSeNa | 195969-09-6

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: nBuSeNa
• 英文别名: Butylselanylsodium
• CAS: 195969-09-6
• 化学式: C₄H₉Se*Na
• 分子量: 159.065
• InChiKey: IOZIXLLJPLHJGA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.62
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  nBuSeNa 、 4-Chloracetylamino-4'-methoxy-diphenylamin 以 乙醇 为溶剂， 以0.09 g的产率得到2-(butylselanyl)-N-(4-((4-methoxyphenyl)amino)phenyl)acetamide
  参考文献：
  名称：

  氨基有机硒化合物作为谷胱甘肽过氧化物酶模拟物和铁死亡抑制剂

  摘要：

  胺有机硒化合物例如对称硒化物和二硒化物可以通过使用硼氢化钠还原其相应的硒氰酸酯而方便地获得。这些化合物表现出非常好的谷胱甘肽过氧化物酶（GPx）样抗氧化活性。它们还在 TAM 诱导的 GPx4 条件敲除细胞系中表现出抗铁死亡活性，并防止生物膜中磷脂氢过氧化物 (LOOH) 的积累。

  DOI：

  10.1002/cbic.202400074
• 作为产物：
  描述：

  二丁基二硒醚 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 nBuSeNa
  参考文献：
  名称：

  氨基有机硒化合物作为谷胱甘肽过氧化物酶模拟物和铁死亡抑制剂

  摘要：

  胺有机硒化合物例如对称硒化物和二硒化物可以通过使用硼氢化钠还原其相应的硒氰酸酯而方便地获得。这些化合物表现出非常好的谷胱甘肽过氧化物酶（GPx）样抗氧化活性。它们还在 TAM 诱导的 GPx4 条件敲除细胞系中表现出抗铁死亡活性，并防止生物膜中磷脂氢过氧化物 (LOOH) 的积累。

  DOI：

  10.1002/cbic.202400074

文献信息

• Synthesis and Glutathione Peroxidase-Like Activities of Isoselenazolines
  作者：Vijay P. Singh、Harkesh B. Singh、Ray J. Butcher

  DOI：10.1002/ejoc.201100899

  日期：2011.10

  substitution (SNAr) reactions of N-(2-bromo-3-nitrobenzyl)aniline (18), N-(2-bromo-3-nitrobenzyl)-4-methylaniline (19) and N-(2-bromo-3-nitrobenzyl)-4-nitroaniline (20) with [nBuSeNa] afford N-[2-(butylselanyl)-3-nitrobenzyl]aniline (21), N-[2-(butylselanyl)-3-nitrobenzyl]-4-methylaniline (22) and N-[2-(butylselanyl)-3-nitrobenzyl]-4-nitroaniline (23), respectively. The bromination of 21 results in the formation

  N-(2-bromo-3-nitrobenzyl)aniline (18), N-(2-bromo-3-nitrobenzyl)-4-methylaniline (19) 和 N-(2-bromo -3-硝基苄基)-4-硝基苯胺 (20) 与 [nBuSeNa] 得到 N-[2-(丁基硒基)-3-硝基苄基]苯胺 (21), N-[2-(丁基硒基)-3-硝基苄基]-4 -甲基苯胺 (22) 和 N-[2-(丁基硒基)-3-硝基苄基]-4-硝基苯胺 (23)。21 的溴化导致环状异硒唑啉 7-硝基-2-苯基-2,3-二氢苯并异硒唑 (27) 和 2-(4-溴苯基)-7-硝基-2,3-二氢苯并异硒唑 (28) 的形成。22 的溴化得到异硒唑啉 2-(4-methylphenyl)-7-nitro-2,3-dihydrobenzisoselenazole (29) 和 2-(2-bromo-4-m
• Nitro-, Azo-, and Amino Derivatives of Ebselen: Synthesis, Structure, and Cytoprotective Effects
  作者：Vijay P. Singh、Jia-fei Poon、Jiajie Yan、Xi Lu、Marjam Karlsson Ott、Ray J. Butcher、Paul J. Gates、Lars Engman

  DOI：10.1021/acs.joc.6b02418

  日期：2017.1.6

  Novel azo-bis-ebselen compounds 7 were prepared by reduction of 7-nitro-2-aryl-1,2-benzisoselenazol-3(2H)-ones 3 and 6 with sodium benzenetellurolate, NaTeC6H5, and by reaction of 2-bromo-3-nitrobenzamides with Na2Se2. The X-ray structure of 7b showed that the molecule, due to strong intramolecular secondary Se···N interactions, is completely planar. Azo-compounds 7 upon further reaction with NaTeC6H5

  新型偶氮-双ebselen化合物7可以通过将7-硝基-2-芳基-1,2-苯并硒代咪唑-3（2 H）-ones 3和6与苯二甲酸钠，NaTeC 6 H 5还原，并通过具有Na 2 Se 2的2-溴-3-硝基苯甲酰胺。7b的X射线结构表明该分子由于强烈的分子内次级Se···N相互作用而完全处于平面状态。与NaTeC 6 H 5进一步反应后的偶氮化合物7将其还原裂解以提供2当量的相应的芳族胺。弱的Se-N键不稳定，无法在反应条件下存活，并且在后处理中分离出二硒化物8。而偶氮二ebselens 7是的谷胱甘肽过氧化物酶（GPx）活性-enzymes的差模拟物，nitroebselens 3，6，和11B和diselenides 8分别为3-6倍依布硒啉更加活跃。基于77 Se NMR光谱，涉及硒基14的二硒化物8b的催化循环，已提出。通过化学发光测量评估，良好的GPx模拟物可以比Trolox更有效
• PROCESSES FOR POLYMERIC PRECURSORS FOR CIS AND CIGS PHOTOVOLTAICS
  申请人：Fujdala Kyle L.

  公开号：US20110034640A1

  公开（公告）日：2011-02-10

  This invention relates to processes for a range of compounds, polymeric compounds, and compositions used to prepare semiconductor and optoelectronic materials and devices including thin film and band gap materials for photovoltaic applications including devices and systems for energy conversion and solar cells. In particular, this invention relates to polymeric precursor compounds and precursor materials for preparing photovoltaic layers. A compound may contain repeating units M A (ER)(ER)} and M B (ER)(ER)}, wherein each M A is Cu, each M B is In or Ga, each E is S, Se, or Te, and each R is independently selected, for each occurrence, from alkyl, aryl, heteroaryl, alkenyl, amido, silyl, and inorganic and organic ligands.

  本发明涉及一系列化合物、聚合物化合物和组合物的过程，用于制备半导体和光电材料和器件，包括用于光伏应用的薄膜和带隙材料，包括用于能量转换和太阳能电池的器件和系统。特别地，本发明涉及用于制备光伏层的聚合物前体化合物和前体材料。化合物可以包含重复单元MA（ER）（ER）}和MB（ER）（ER）}，其中每个MA是Cu，每个MB是In或Ga，每个E是S、Se或Te，每个R独立地从烷基、芳基、杂环芳基、烯基、酰胺基、硅基和无机和有机配体中选取，对于每个出现的情况都是如此。
• Synthesis and preliminary biological evaluation for the anticancer activity of organochalcogen (S/se) tethered chrysin-based organometallic Ru^II(η⁶-p-cymene) complexes
  作者：Shipra Yadav、Jai Deo Singh

  DOI：10.1080/07391102.2018.1513867

  日期：2019.9.2

  Organochalcogen (S/Se) functionalized chrysin derivatives were synthesized and coordinated with Ru-II(eta(6)-p-cymene) to efficiently form ruthenium-based chemotherapeutic drug entities [C31H35O4SRuCl]; [C31H35O4SeRuCl]; [C33H31O4SRuCl]; and [C33H31O4SeRuCl]. The complexes were thoroughly characterized by analytical and various spectroscopic techniques which include elemental analysis, UV-vis, IR, NMR (H-1, C-13, and Se-77 NMR), and HR-MS. The interaction studies of these Ru(II) complexes were carried out with CT DNA/HSA by employing UV-vis, fluorescence and circular dichroic techniques in view to examine their chemotherapeutic potential. The complexes demonstrated predominant binding toward CTDNA via electrostatic interaction while, the extent of binding was quantified by calculating intrinsic binding constant (K-b) and binding constant (K) values which revealed higher binding affinity of selenium-based chrysin complexes as compared to their thio-analogs, following the order [C31H35O4SeRuCl] > [C33H31O4SeRuCl] > [C31H35O4SRuCl] > [C33H31O4SRuCl]. Moreover, interaction of these complexes with human serum albumin (HSA) was also investigated which suggested spontaneous interactions of complexes with the protein by hydrogen bonding and van der Waals forces. To visualize the preferential binding sites and affinity of complexes with DNA and HSA molecular docking studies were performed. Additionally, in vitro anticancer activity of the complexes were evaluated by SRB assay on selected cancer cell lines viz., HeLa (cervical), MIA-PA-CA-2 (pancreatic), MCF-7 (breast), Hep-G2 (Hepatoma), and SK-OV-3 (ovarian) which exhibited the superior cytotoxicity of complex [C31H35O4SeRuCl] as compared to other analogs on selective cancer phenotypes.[GRAPHICS].
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Ge: SVol., 114, page 519 - 521
  作者：

  DOI：——

  日期：——