1-[3-chloro-4-[4-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]phenyl]-N-(2,2,2-trifluoroethyl)piperidine-4-carboxamide | 851766-32-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-[3-chloro-4-[4-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]phenyl]-N-(2,2,2-trifluoroethyl)piperidine-4-carboxamide
• CAS: 851766-32-0
• 化学式: C₂₆H₂₇ClF₃N₅O
• 分子量: 517.981
• InChiKey: VSGCGUQKLXXHSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  63
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Triazole Compounds and Uses Related Thereto
  申请人：Powers Jay P.

  公开号：US20080249084A1

  公开（公告）日：2008-10-09

  The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound is useful as a therapeutic drug for the treatment of diabetes, obesity or metabolic syndrome.
• TRIAZOLE COMPOUNDS AND USES RELATED THERETO
  申请人：POWERS JAY P.

  公开号：US20100062972A1

  公开（公告）日：2010-03-11

  The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound has superior HSD1 inhibitory activity, and is useful as an HSD1 inhibitor, a therapeutic drug of diabetes or a therapeutic drug of obesity or a therapeutic drug of metabolic syndrome.
• US7683059B2
  申请人：——

  公开号：US7683059B2

  公开（公告）日：2010-03-23
• US8153631B2
  申请人：——

  公开号：US8153631B2

  公开（公告）日：2012-04-10