3-(2,6-dichlorophenyl)-7-{[4-(4-hydroxypiperidin-1-yl)-3-methylphenyl]amino}pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione | 1229431-78-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(2,6-dichlorophenyl)-7-{[4-(4-hydroxypiperidin-1-yl)-3-methylphenyl]amino}pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
• 英文别名: 6-(2,6-dichlorophenyl)-2-[4-(4-hydroxypiperidin-1-yl)-3-methylanilino]-8H-pyrimido[4,5-d]pyrimidine-5,7-dione
• CAS: 1229431-78-0
• 化学式: C₂₄H₂₂Cl₂N₆O₃
• 分子量: 513.383
• InChiKey: BASWGYPPHHLRPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  111
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVES<br/>[FR] DÉRIVÉS DE DIHYDROPYRIMIDOPIRYMIDINE
  申请人：BANYU PHARMA CO LTD

  公开号：WO2010067888A1

  公开（公告）日：2010-06-17

  The invention relates to compounds represented by the general formula (I) and the like. In the formula, Ar1 denotes an aryl or heteroaryl group which may have a substituent; R1 denotes a hydrogen atom, or denotes a C1-C6 alkyl, aryl, aralkyl or heteroaryl group which may have a substituent; R2 denotes an aralkyl group or a group represented by the formula (a); and R3 denotes a hydrogen atom or a C1-C6 alkyl group. The compounds of the invention have an excellent Weel kinase inhibitory effect, and therefore are useful in the field of medicine, especially in the field of treatment of various cancers.

  本发明涉及由一般式(I)等表示的化合物。在该式中，Ar1表示可能具有取代基的芳基或杂环芳基；R1表示氢原子，或表示可能具有取代基的C1-C6烷基，芳基，芳基烷基或杂环芳基；R2表示芳基烷基或由式(a)表示的基团；R3表示氢原子或C1-C6烷基。本发明的化合物具有优异的Weel激酶抑制作用，因此在医学领域，特别是在各种癌症治疗领域中非常有用。
• DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVES
  申请人：Bamba Makoto

  公开号：US20110245229A1

  公开（公告）日：2011-10-06

  The invention relates to compounds represented by the general formula (I) and the like. In the formula, Ar 1 denotes an aryl or heteroaryl group which may have a substituent; R 1 denotes a hydrogen atom, or denotes a C1-C6 alkyl, aryl, aralkyl or heteroaryl group which may have a substituent; R 2 denotes an aralkyl group or a group represented by the formula (a); and R 3 denotes a hydrogen atom or a C1-C6 alkyl group. The compounds of the invention have an excellent Weel kinase inhibitory effect, and therefore are useful in the field of medicine, especially in the field of treatment of various cancers.

  本发明涉及由通式（I）等表示的化合物。在该式中，Ar1表示可能具有取代基的芳基或杂环芳基基团；R1表示氢原子，或表示可能具有取代基的C1-C6烷基，芳基，芳基烷基或杂环芳基基团；R2表示芳基烷基或由式（a）表示的基团；R3表示氢原子或C1-C6烷基基团。本发明的化合物具有出色的Weel激酶抑制作用，因此在医学领域，特别是在各种癌症治疗领域中非常有用。
• DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVES
  申请人：MSD K.K.

  公开号：EP2376494A1

  公开（公告）日：2011-10-19
• US8575179B2
  申请人：——

  公开号：US8575179B2

  公开（公告）日：2013-11-05