4-哌啶基哌啶二盐酸盐 | 4876-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-哌啶基哌啶二盐酸盐
• 中文别名: 1,4-联哌啶二盐酸盐
• 英文名称: 1,4'-Bipiperidine dihydrochloride
• 英文别名: 1-piperidin-4-ylpiperidine;dihydrochloride
• CAS: 4876-60-2
• 化学式: C10H22Cl2N2
• mdl: MFCD06658209
• 分子量: 241.2
• InChiKey: BBQDEKNMSAXDAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.68
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933399090

文献信息

• Arylmethoxy Isoindoline Derivatives and Compositions Comprising and Methods of Using the Same
  申请人：Man Hon-Wah

  公开号：US20110196150A1

  公开（公告）日：2011-08-11

  Provided are 4′-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

  提供了4'-芳基甲氧基异吲哚啉化合物，以及其药用盐、溶剂合物、包合物、立体异构体和前药。公开了这些化合物的使用方法和药物组合物。
• IL-5 inhibiting 6-azauracil derivatives
  申请人：——

  公开号：US20020010177A1

  公开（公告）日：2002-01-24

  The present invention is concerned with the compounds of formula 1 the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 4; X is O, S, NR 5 or a direct bond; Y is O, S, NR 5 or S(O) 2 ; R 1 independently is C 1-6 alkyl, halo, polyhaloC 1-6 alkyl, hydroxy, mercapto, C 1-6 alkyloxy, C 1-6 alkylthio, C 1-6 alkylcarbonyloxy, aryl, cyano, nitro, Het 3 , R 6 , NR 7 R 8 or substituted C 1-4 alkyl; R 2 is Het 1 , C 3-7 cycloalkyl or optionally substituted C 1-6 alkyl and if X is O, S or NR 5 , then R 2 may also represent aminocarbonyl, aminothiocarbonyl, C 1-4 alkylcarbonyl, C 1-4 alkylthiocarbonyl, arylcarbonyl, arylthiocarbonyl, Het 1 carbonyl or Het 1 thiocarbonyl; R 3 and R 4 independently are hydrogen, C 1-6 alkyl or C 3-7 cycloalkyl; R 3 and R 4 form a C 2-6 alkanediyl; R 5 is hydrogen or C 1-4 alkyl; R 6 is a sulfonyl or sulfinyl derivative; R 7 and R 8 are independently hydrogen, optionally substituted C 1-4 alkyl, aryl, a carbonyl containing moiety, C 3-7 cycloalkyl, —Y—C 1-4 alkanediyl-C(=O)—O—R 14 , Het 3 , Het 4 and R 6 ; R 11 is hydroxy, mercapto, cyano, nitro, halo, trihalomethyl, C 1-4 alkyloxy, formyl, trihaloC 1-4 alkylsulfonyloxy, R 6 , RNR 7 R 8 , C(=O)NR 7 R 8 , C 1-4 alkanediyl-C(=O)—O—R 14 , —C(=O)—O—R 14 , —Y—C 1-4 alkanediyl-C(=O)—O—R 14 , aryl, aryloxy, arylcarbonyl, C 3-7 cycloalkyl, C 3-7 cycloalkyloxy, phthalimide-2-yl, Het 3 and C(=O)Het 3 ; R 14 is hydrogen, C 1-4 alkyl, C 3-7 cycloalkyl, aminocarbonylmethylene or mono-or di(C 1-4 alkyl)aminocarbonylmethylene; aryl is optionally substituted phenyl; Het 1 , Het 2 , Het 3 and Het 4 are optionally substituted heterocycles; to processes for their preparation and compositions comprising them. It further relates to their use as a medicine.

  本发明涉及公式1的化合物，包括N-氧化物、药学上可接受的加合盐及其立体化异构体，其中p为0至4；X为O、S、NR5或直接键；Y为O、S、NR5或S(O)2；R1独立地为C1-6烷基、卤素、多卤代C1-6烷基、羟基、巯基、C1-6烷氧基、C1-6烷硫基、C1-6烷基羰氧基、芳基、氰基、硝基、Het3、R6、NR7R8或取代的C1-4烷基；R2为Het1、C3-7环烷基或可选择取代的C1-6烷基，如果X为O、S或NR5，则R2也可以表示氨基羰基、氨基硫代羰基、C1-4烷基羰基、C1-4烷基硫代羰基、芳基羰基、芳基硫代羰基、Het1羰基或Het1硫代羰基；R3和R4独立地为氢、C1-6烷基或C3-7环烷基；R3和R4形成一个C2-6烷二基；R5为氢或C1-4烷基；R6为磺酰基或亚砜衍生物；R7和R8独立地为氢、可选择取代的C1-4烷基、芳基、含羰基的基团、C3-7环烷基、—Y—C1-4烷二基-C(=O)—O—R14、Het3、Het4和R6；R11为羟基、巯基、氰基、硝基、卤素、三卤甲基、C1-4烷氧基、甲酰基、三卤代C1-4烷基磺酰氧基、R6、RNR7R8、C(=O)NR7R8、C1-4烷二基-C(=O)—O—R14、—C(=O)—O—R14、—Y—C1-4烷二基-C(=O)—O—R14、芳基、芳氧基、芳基羰基、C3-7环烷基、C3-7环烷氧基、邻苯二酰亚胺-2-基、Het3和C(=O)Het3；R14为氢、C1-4烷基、C3-7环烷基、氨基羰基亚甲基或单烷基或双(C1-4烷基)氨基羰基亚甲基；芳基为可选择取代的苯基；Het1、Het2、Het3和Het4为可选择取代的杂环；以及其制备方法和含有它们的组合物。进一步涉及它们作为药物的用途。
• ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
  申请人：Celgene Corporation

  公开号：US20180037567A1

  公开（公告）日：2018-02-08

  Provided are 4′-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

  提供了4'-芳基甲氧基异吲哚啉化合物及其药学上可接受的盐、溶剂合物、笼合物、立体异构体和前药。公开了这些化合物的使用方法和药物组合物。
• Interleukin-5 inhibiting 6-azauracil derivatives
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0987265A1

  公开（公告）日：2000-03-22

  The present invention is concerned with the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 4; X is O, S, NR5 or a direct bond; Y is O, S, NR5 or S(O)2; R1 independently is C1-6alkyl, halo, polyhaloC1-6alkyl, hydroxy, mercapto, C1-6alkyloxy, C1-6alkylthio, C1-6alkylcarbonyloxy, aryl, cyano, nitro, Het3, R6, NR7R8 or substituted C1-4alkyl; R2 is Het1, C3-7cycloalkyl or optionally substituted C1-6alkyl and if X is O, S or NR5, then R2 may also represent aminocarbonyl, aminothiocarbonyl, C1-4alkylcarbonyl, C1-4alkylthiocarbonyl, arylcarbonyl, arylthiocarbonyl, Het1carbonyl or Het1thiocarbonyl; R3 and R4 independently are hydrogen, C1-6alkyl or C3-7cycloalkyl; R3 and R4 form a C2-6alkanediyl; R5 is hydrogen or C1-4alkyl; R6 a sulfonyl or sulfinyl derivative; R7 and R8 are independently hydrogen, optionally substituted C1-4alkyl, aryl, a carbonyl containing moiety, C3-7cycloalkyl, -Y-C1-4alkanediyl-C(=O)-O-R14, Het3 and R6; R11 is hydroxy, mercapto, cyano, nitro, halo, trihalomethyl, C1-4alkyloxy, formyl, trihaloC1-4alkylsulfonyloxy, R6, NR7R8, C(=O)NR7R8, C1-4alkanediyl-C(=O)-O-R14, - C(=O)-O-R14, -Y-C1-4alkanediyl-C(=O)-O-R14, aryl, aryloxy, arylcarbonyl, C3-7cycloalkyl, C3-7cycloalkyloxy, phthalimide-2-yl, Het3, Het4 and C(=O)Het3; R14 is hydrogen, C1-4alkyl, C3-7cycloalkyl, aminocarbonylmethylene or mono-or di(C1-4alkyl)aminocarbonylmethylene; aryl is optionally substituted phenyl; Het1, Het2, Het3 and Het4 are optionally substituted heterocycles; to processes for their preparation and compositions comprising them. It further relates to their use as a medicine.

  本发明涉及式化合物 其中 p 为 0 至 4；X 为 O、S、NR5 或直接键；Y 为 O、S、NR5 或 S(O)2；R1 独立地为 C1-6 烷基、卤代、多卤代 C1-6 烷基、羟基、巯基、C1-6 烷氧基、C1-6 烷硫基、C1-6 烷基羰基氧基、芳基、氰基、硝基、Het3、R6、NR7R8 或取代的 C1-4 烷基；R2 是 Het1、C3-7 环烷基或任选取代的 C1-6 烷基，如果 X 是 O、S 或 NR5，则 R2 还可以代表氨基羰基、氨基硫代羰基、C1-4烷基羰基、C1-4烷基硫代羰基、芳基羰基、芳基硫代羰基、Het1羰基或 Het1硫代羰基；R3 和 R4 独立地为氢、C1-6烷基或 C3-7 环烷基；R3 和 R4 形成 C2-6 烷二基；R5 为氢或 C1-4 烷基；R6 为磺酰基或亚磺酰基衍生物；R7 和 R8 独立地是氢、任选取代的 C1-4 烷基、芳基、含羰基的分子、C3-7 环 烷基、-Y-C1-4 烷二基-C(=O)-O-R14、Het3 和 R6；R11 是羟基、巯基、氰基、硝基、卤代、三卤甲基、C1-4 烷氧基、甲酰基、三卤 C1-4 烷基磺酰氧基、R6、NR7R8、C(=O)NR7R8、C1-4烷二基-C(=O)-O-R14、- C(＝O)-O-R14、-Y-C1-4烷二基-C(＝O)-O-R14、芳基、芳氧基、芳羰基、C3-7 环烷基、C3-7 环烷氧基、邻苯二甲酰亚胺-2-基、Het3、Het4 和 C(＝O)Het3；R14是氢、C1-4烷基、C3-7环烷基、氨基羰基亚甲基或单或二(C1-4烷基)氨基羰基亚甲基；芳基是任选取代的苯基；Het1、Het2、Het3和Het4是任选取代的杂环；还涉及它们的制备工艺和包含它们的组合物。还涉及它们作为药物的用途。
• Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
  申请人：Celgene Corporation

  公开号：US10189814B2

  公开（公告）日：2019-01-29

  Provided are 4′-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

  本发明提供了 4′-芳基甲氧基异吲哚啉化合物及其药学上可接受的盐、溶液剂、凝胶体、立体异构体和原药。还公开了这些化合物的使用方法和药物组合物。