2,3,4,4a,5,6,7,8-octahydro-cinnoline | 37721-12-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 2,3,4,4a,5,6,7,8-octahydro-cinnoline
• 英文别名: 2,3,4,4a,5,6,7,8-Octahydrocinnoline
• CAS: 37721-12-3
• 化学式: C₈H₁₄N₂
• 分子量: 138.213
• InChiKey: GNAPLCOKRBSOAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• THE USE OF N-ARYL DIAZASPIRACYCLIC COMPOUNDS IN THE TREATMENT OF ADDICTION
  申请人：Targacept, Inc.

  公开号：EP1784184A2

  公开（公告）日：2007-05-16
• [EN] THE USE OF N-ARYL DIAZASPIRACYCLIC COMPOUNDS IN THE TREATMENT OF ADDICTION<br/>[FR] UTILISATION DE COMPOSES DIAZASPIRACYCLIQUES N-ARYLE DANS LE TRAITEMENT DE LA TOXICOMANIE
  申请人：TARGACEPT INC

  公开号：WO2006023630A2

  公开（公告）日：2006-03-02

  Compounds, compositions and methods for treating drug addiction, nicotine addiction, and/or obesity are disclosed. The compounds are N-aryl diazaspirocyclic compounds, bridged analogs of N-heteraryl diazaspirocyclic compounds, or prodrugs or metabolites of these compounds. The aryl group can be a five- or six-membered heterocyclic ring (heteroaryl). The compounds are effective at inhibiting dopamine production and/or secretion, and accordingly are effective at inhibiting the physiological 'reward' process that is associated with ingestion of nicotine and/or illicit drugs. The compounds and compositions can be administered in effective amounts to inhibit dopamine release, wihout resulting in appreciable adverse side effects (e.g., side effects such as significant increases in blood pressure and heart rate, significant negative effects upon the gastro-intestinal tract, and significant effects upon skeletal muscle).