2-(2-(1-benzothiophen-3-yl)ethoxy)-1-(3-hydroxy-1-pyrrolidinyl)-1-ethanone | 519188-61-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-(2-(1-benzothiophen-3-yl)ethoxy)-1-(3-hydroxy-1-pyrrolidinyl)-1-ethanone
• 英文别名: 2-[2-(1-Benzothiophen-3-yl)ethoxy]-1-(3-hydroxypyrrolidin-1-yl)ethanone
• CAS: 519188-61-5
• 化学式: C₁₆H₁₉NO₃S
• 分子量: 305.398
• InChiKey: OEBPTZGSKOOHAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  78
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Alkyl ether derivatives or salts thereof
  申请人：Saitoh Akihito

  公开号：US20060194781A1

  公开（公告）日：2006-08-31

  An alkyl ether derivative represented by the general formula: wherein each of R 1 and R 2 represents one or more groups selected from a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group, an alkenyl group, an alkenyloxy group, an amino group, an alkylsulfonyl group, an arylsulfonyl group, a carbamoyl group, a heterocyclic group, a hydroxyl group, a carboxyl group, a nitro group, an oxo group and the like; R 3 is an alkylamino group, an amino group, a hydroxyl group or the like; the ring A is a 5-membered or 6-membered heteroaromatic ring or a benzene ring; each of m and n is an integer of 1 to 6; and p is an integer of 1 to 3, or its salt has activity to protect neurons, activity to accelerate nerve regeneration and activity to accelerate neurite extension and hence is useful as a therapeutic agent for diseases in central and peripheral nerves.

  一种烷基醚衍生物，其通式表示为：其中R1和R2各自表示氢原子、卤素原子、烷基、芳基、芳基烷基、烷氧基、芳氧基、烷硫基、芳硫基、烯基、烯氧基、氨基、烷基磺酰基、芳基磺酰基、氨基甲酰基、杂环基、羟基、羧基、硝基、氧代基等一种或多种基团；R3是烷基氨基、氨基、羟基等一种或多种基团；环A是5元或6元杂芳环或苯环；m和n各自是1到6的整数；p是1到3的整数，或其盐具有保护神经元、加速神经再生和加速神经突起延伸的活性，因此可用作治疗中枢和外周神经疾病的治疗剂。
• Preventive/remedy for retinal nerve diseases containing alkyl ether derivatives or salts thereof
  申请人：Kimura Tatsuo

  公开号：US20060205709A1

  公开（公告）日：2006-09-14

  An alkyl ether derivative represented by the following general formula [1] or its salt: wherein R 1 and R 2 represent each a substituent such as hydrogen, halogeno or alkyl; R 3 represents alkylamino, amino or hydroxyl; the ring A represents a 5- or 6-membered aromatic heterocycle or a benzene ring; m and n are each an integer of from 1 to 6; and p is an integer of from 1 to 3; shows an effect of protecting retinal nerve cells and, therefore, is useful as a preventive and/or a remedy for retinal nerve diseases such as glaucoma, diabetic retinopathy, retinal artery obstruction, retinal venous obstruction, macular degeneration and retinopathy of prematurity.

  一种烷基醚衍生物，由以下通式[1]或其盐所表示：其中R1和R2分别表示氢、卤素或烷基等取代基；R3表示烷基氨基、氨基或羟基；环A表示5-或6-成员芳香杂环或苯环；m和n均为1至6的整数；p为1至3的整数；具有保护视网膜神经细胞的效果，因此可用作预防和/或治疗青光眼、糖尿病视网膜病变、视网膜动脉阻塞、视网膜静脉阻塞、黄斑变性和早产儿视网膜病变等视网膜神经病变的药物。
• PREVENTIVE/REMEDY FOR RETINAL NERVE DISEASES CONTAINING ALKYL ETHER DERIVATIVES OR SALTS THEREOF
  申请人：KIMURA Tatsuo

  公开号：US20100075941A1

  公开（公告）日：2010-03-25

  An alkyl ether derivative represented by the following general formula [1] or its salt: wherein R 1 and R 2 represent each a substituent such as hydrogen, halogeno or alkyl; R 3 represents alkylamino, amino or hydroxyl; the ring A represents a 5- or 6-membered aromatic heterocycle or a benzene ring; m and n are each an integer of from 1 to 6; and p is an integer of from 1 to 3; shows an effect of protecting retinal nerve cells and, therefore, is useful as a preventive and/or a remedy for retinal nerve diseases such as glaucoma, diabetic retinopathy, retinal artery obstruction, retinal venous obstruction, macular degeneration and retinopathy of prematurity.

  一种烷基醚衍生物，其通式[1]或其盐：其中R1和R2分别表示氢、卤素或烷基等取代基；R3表示烷基氨基、氨基或羟基；环A表示5或6成员的芳香杂环或苯环；m和n分别为1至6的整数；p为1至3的整数；具有保护视网膜神经细胞的作用，因此可用作预防和/或治疗青光眼、糖尿病视网膜病变、视网膜动脉阻塞、视网膜静脉阻塞、黄斑变性和早产儿视网膜病变的药物。
• ALKYL ETHER DERIVATIVES OR SALTS THEREOF
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP1437353B1

  公开（公告）日：2007-06-13
• US7087594B2
  申请人：——

  公开号：US7087594B2

  公开（公告）日：2006-08-08