N-(3,5-bis(trifluoromethyl)benzyl)-4-(cyclopropylmethyl)-1-((2-oxo-2H-chromen-7-yl)methyl)piperidine-4-carboxamide | 1018992-38-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(3,5-bis(trifluoromethyl)benzyl)-4-(cyclopropylmethyl)-1-((2-oxo-2H-chromen-7-yl)methyl)piperidine-4-carboxamide
• 英文别名: N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-(cyclopropylmethyl)-1-[(2-oxochromen-7-yl)methyl]piperidine-4-carboxamide
• CAS: 1018992-38-5
• 化学式: C₂₉H₂₈F₆N₂O₃
• 分子量: 566.543
• InChiKey: PYAFDZQFRPZRFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  40
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• [EN] CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR<br/>[FR] COMPOSÉS DE CARBOXYAMIDE ET LEUR UTILISATION COMME ANTAGONISTES DU RÉCEPTEUR CCR2DE LA CHIMIOKINE
  申请人：EPIX DELAWARE INC

  公开号：WO2009076404A1

  公开（公告）日：2009-06-18

  Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described; wherein (B/A) is an optionally substituted fused aromatic or partially aromatic bicyclic ring containing at least one nitrogen atom.

  描述了特定的化学物质，即作为趋化因子CCR2受体拮抗剂的Formula (I)化合物，包括其药用组合物和用途，用于治疗或预防与单核细胞、淋巴细胞或白细胞聚积相关的疾病；其中(B/A)是一个可选择地取代的融合芳香或部分芳香的双环环，其中至少含有一个氮原子。
• CARBOXAMIDE COMPOUNDS AND THEIR USE
  申请人：Lin Jian

  公开号：US20100210633A1

  公开（公告）日：2010-08-19

  Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.

  本文介绍了化学因子受体拮抗剂，特别是公式(I)化合物，它们作为化学因子CCR2受体的拮抗剂，包括制药组合物及其用途，用于治疗或预防与单核细胞聚集、淋巴细胞聚集或白细胞聚集相关的疾病。
• Carboxamide Compounds and Their Use
  申请人：Ben-Zeev Efrat

  公开号：US20100331298A1

  公开（公告）日：2010-12-30

  Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.

  本文描述了化学因子受体拮抗剂，特别是式（I）化合物，其作为趋化因子CCR2受体的拮抗剂，包括制药组合物及其用于治疗或预防与单核细胞聚集、淋巴细胞聚集或白细胞聚集相关的疾病。