2-Methyltriazolo<4,5-c>pyridin | 3678-84-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡啶类
• 英文名称: 2-Methyltriazolo<4,5-c>pyridin
• 英文别名: 2-methyl-2H-[1,2,3]triazolo[4,5-c]pyridine；2-Methyltriazolo[4,5-c]pyridine
• CAS: 3678-84-0
• 化学式: C₆H₆N₄
• 分子量: 134.14
• InChiKey: JRQDMGUPPUSJQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• USE OF DIBENZOFURANS AND DIBENZOTHIOPHENES SUBSTITUTED BY NITROGEN-BONDED FIVE-MEMBERED HETEROCYCLIC RINGS IN ORGANIC ELECTRONICS
  申请人：LANGER Nicolle

  公开号：US20120007063A1

  公开（公告）日：2012-01-12

  The present invention relates to the use of dibenzofurans and dibenzothiophenes which have at least one nitrogen-bonded five-membered heterocyclic ring as a substituent as host, blocker and/or charge transport material in organic electronics. The present invention further relates to dibenzofurans and dibenzothiophenes which comprise at least one nitrogen-bonded five-membered heterocyclic ring and at least one carbazolyl radical as substituents, to a process for preparation thereof, and to the use of these compounds in organic electronics.

  本发明涉及在有机电子器件中将至少含有一个氮键合的五元杂环环作为取代基的二苯并呋喃和二苯并噻吩用作主体、阻挡剂和/或电荷传输材料。本发明还涉及至少含有一个氮键合的五元杂环环和至少一个咔唑基团作为取代基的二苯并呋喃和二苯并噻吩，以及其制备方法和在有机电子器件中的应用。
• FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES
  申请人：BAYER CROPSCIENCE AKTIENGESELLSCHAFT

  公开号：US20180116222A1

  公开（公告）日：2018-05-03

  The invention relates to novel compounds of the formula (I) in which R 1 , R 2 , R 3 , Q and n have the meanings given above, to their use as acaricides and/or insecticides for controlling animal pests and to processes and intermediates for their preparation.

  本发明涉及公式（I）的新化合物，其中R1，R2，R3，Q和n具有上述给定的含义，它们用作杀螨剂和/或杀虫剂以控制动物害虫，并提供它们的制备过程和中间体。
• PRMT5 INHIBITORS AND USES THEREOF
  申请人：Epizyme, Inc.

  公开号：US20150191432A1

  公开（公告）日：2015-07-09

  Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

  本文描述了公式（I）的化合物，其药学上可接受的盐和制药组合物。本发明的化合物对于抑制PRMT5活性是有用的。还描述了使用这些化合物治疗PRMT5介导的疾病的方法。
• PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF
  申请人：EPIZYME, INC.

  公开号：US20150344433A1

  公开（公告）日：2015-12-03

  Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

  本文描述了公式（A）的化合物，其药学上可接受的盐和药物组合物。本发明的化合物可用于抑制PRMT5活性。还描述了使用这些化合物治疗PRMT5介导的疾病的方法。
• 19-NOR NEUROACTIVE STEROIDS FOR INDUCING SEDATION
  申请人：Sage Therapeutics, Inc.

  公开号：EP3719030A1

  公开（公告）日：2020-10-07

  Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): and pharmaceutical compositions thereof for inducing sedation. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, and status epilepticus.

  本文提供的是符合式（I）的 3,3-二取代 19-去甲甾醇化合物： 及其药物组合物，用于诱导镇静。此类化合物可用于预防和治疗各种中枢神经系统相关疾病，例如，治疗睡眠障碍、情绪障碍、精神分裂症谱系障碍、记忆和/或认知障碍、运动障碍、人格障碍、自闭症谱系障碍、疼痛、脑外伤、血管疾病、药物滥用障碍和/或戒断综合征、耳鸣和癫痫状态。