N,N-Pentamethylen-formamid-chlorid | 89599-67-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N,N-Pentamethylen-formamid-chlorid
• 英文别名: Pentamethylenformamid-chlorid；1-dichloromethyl-piperidine；1-(Dichloromethyl)piperidine
• CAS: 89599-67-7
• 化学式: C₆H₁₁Cl₂N
• 分子量: 168.066
• InChiKey: YWHSOIPKRYVJHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Indole derivatives, process for preparation of the same and use thereof
  申请人：——

  公开号：US20030176400A1

  公开（公告）日：2003-09-18

  Indole derivatives represented by formula (I): 1 (wherein all symbols are described in the description), a process for the preparation of the same and a DP receptor antagonist comprising it as an active ingredient. Since the compounds of formula (I) binds to and are antagonistic to a DP receptor, they are useful in for the prevention and/or treatment of diseases, for example, allergic diseases (allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma, food allergy, etc., systemic mastocytosis; disorders due to systemic mastocyte activation, anaphylactic shock, bronchoconstriction, urticaria, eczema, etc.), diseases accompanied with itching (atopic dermatitis, urticaria, etc.), secondary diseases caused by behaviors (scratching behaviors, beating, etc.) (cataract, retinal detachment, inflammation, infection, sleep disorder, etc.), inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, cerebrovascular disorder, pleuritis complicated by rheumatoid arthritis, ulcerative colitis, and the like.

  Indole 衍生物的化学式（I）：1（其中所有符号在描述中有描述），以及制备该化合物的方法和作为活性成分的 DP 受体拮抗剂。由于化合物的化学式（I）与 DP 受体结合并具有拮抗作用，因此它们在预防和/或治疗疾病方面非常有用，例如过敏性疾病（过敏性鼻炎、过敏性结膜炎、特应性皮炎、支气管哮喘、食物过敏等）、全身肥大细胞增多症；由于全身肥大细胞激活引起的疾病、过敏性休克、支气管痉挛、荨麻疹、湿疹等）、伴有瘙痒的疾病（特应性皮炎、荨麻疹等）、由行为引起的继发性疾病（搔抓行为、殴打等）（白内障、视网膜脱离、炎症、感染、睡眠障碍等）、炎症、慢性阻塞性肺病、缺血再灌注障碍、脑血管障碍、风湿性关节炎并发的胸膜炎、溃疡性结肠炎等。
• Bioluminescent protease assay
  申请人：——

  公开号：US20030211560A1

  公开（公告）日：2003-11-13

  A sensitive bioluminescent assay to detect proteases including caspases, trypsin and tryptase is provided.

  提供了一种敏感的生物发光酶测定法，用于检测蛋白酶，包括半胱氨酸蛋白酶、胰蛋白酶和色氨酸蛋白酶。
• Cyclic peptide
  申请人：——

  公开号：US20040063625A1

  公开（公告）日：2004-04-01

  A novel cyclic peptide having an antifungal activity, its pharmacologically acceptable salts and antifungal medicinal compositions containing the same.

  一种具有抗真菌活性的新型环状肽，其药理学上可接受的盐以及含有该肽的抗真菌药物组合物。
• Fatty acid carriers for synthetic vaccines
  申请人：New York Blood Center, Inc.

  公开号：EP0093851A2

  公开（公告）日：1983-11-16

  A synthetic vaccine is contemplated comprising a peptide residue coupled to one or more alkyl or alkenyl groups of at least 12 carbon atoms or other lipophilic substance wherein said peptide residue contains a sequence of 6 amino acids corresponding to the sequence of such amino acids In a protein antigen or allergen where the greatest local average hydrophilicity of the antigen or allergen is found.

  考虑一种合成疫苗，它包含一个肽残基，该肽残基与一个或多个至少 12 个碳原子的烷基或烯基或其他亲脂性物质偶联，其中所述肽残基包含与蛋白质抗原或过敏原中此类氨基酸序列相对应的 6 个氨基酸序列，而抗原或过敏原的最大局部平均亲水性就在该氨基酸序列中。
• Stabilization of somatotropins and other proteins by modification of cysteine residues
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0458064A2

  公开（公告）日：1991-11-27

  The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing said derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.

  本发明涉及具有生理活性的衍生化天然和重组哺乳动物及人类蛋白质和多肽。本发明提供了对天然和重组衍生的含有半胱氨酸残基的蛋白质或多肽进行衍生化的化学方法，衍生化可以是天然的，也可以是通过位点特异性诱变剂进行的。含有上述衍生化蛋白质和/或多肽的药物组合物配制成稳定、长效的此类蛋白质和/或多肽组合物，这在以前是很难实现的。