| 1380433-01-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 1380433-01-1
• 化学式: C₁₁₃H₁₇₂N₇O₂₀P
• 分子量: 1979.62
• InChiKey: IRDLQYUPZKLCTC-ZOTZSKGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  25.34
• 重原子数：
  141.0
• 可旋转键数：
  77.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  319.03
• 氢给体数：
  2.0
• 氢受体数：
  23.0

反应信息

• 作为产物：
  描述：

  [(2R,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] 4-oxo-4-[4-(3,4,5-trioctadecoxybenzoyl)piperazin-1-yl]butanoate 、 cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidine-3'-yl N-diisopropylphosphoramidate 在 5-苄硫基四氮唑 、 2-过氧化丁酮 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 0.5h， 以99%的产率得到
  参考文献：
  名称：

  Liquid-Phase RNA Synthesis by Using Alkyl-Chain-Soluble Support

  摘要：

  AbstractRecent progress in the RNA therapeutics has increased demand for the synthesis of large quantities of oligoribonucleotides. The assembly of RNA oligomers relies mainly on solid‐phase approaches. These allow rapid product purification and the ability to drive a target reaction to completion through the use of excess reagents. Despite the known advantages of solid‐phase synthesis, some issues in the process remain to be addressed, such as low and limited scale, reagent accessibility, and the use of a very large excess of reagents. Herein, we report a highly efficient and practical method of liquid‐phase synthesis of RNA oligomers by using alkyl‐chain‐soluble support. We demonstrate the utility of the liquid‐phase method through 21‐mer RNA synthesis on a gram scale.

  DOI：

  10.1002/chem.201300655