(+/-)-1-Hydroxy-2,2,3,5,5-pentamethyl-pyrrolidin | 4538-97-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (+/-)-1-Hydroxy-2,2,3,5,5-pentamethyl-pyrrolidin
• 英文别名: 2,2,3,5,5-pentamethyl-pyrrolidin-1-ol；1-Hydroxy-2,2,3,5,5-pentamethylpyrrolidine
• CAS: 4538-97-0
• 化学式: C₉H₁₉NO
• 分子量: 157.256
• InChiKey: REIRZSNTXASSGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Drug Resistance Reversal In Neoplastic Disease
  申请人：Patil Ghanshyam

  公开号：US20080200405A1

  公开（公告）日：2008-08-21

  The present invention is directed to compounds, compositions, and methods for halting or reversing the effects of chemoresistance in neoplastic diseases. In particular the use of hydroxylamines is described.

  本发明涉及用于阻止或逆转肿瘤性疾病化疗耐药效应的化合物、组合物和方法。具体描述了羟胺的使用。
• [EN] NITROXIDE CONTAINING AMYLOID BINDING AGENTS FOR IMAGING AND THERAPEUTIC USES<br/>[FR] AGENTS DE LIAISON À L'AMYLOÏDE CONTENANT DU NITROXYDE UTILISÉS EN IMAGERIE ET À DES FINS THÉRAPEUTIQUES
  申请人：UNIV CALIFORNIA

  公开号：WO2017031239A1

  公开（公告）日：2017-02-23

  The present invention provides methods of using nitroxide spin-labeled amyloid beta-binding compounds to image amyloid. The present invention also provides nitroxide spin-labeled amyloid beta-binding compounds

  本发明提供了使用亚硝基自旋标记的淀粉样β结合化合物来成像淀粉样物质的方法。本发明还提供了亚硝基自旋标记的淀粉样β结合化合物。
• Highly efficient polarizing agents for dynamic nuclear polarization
  申请人：Bruker Biospin (SAS)

  公开号：EP2789609A1

  公开（公告）日：2014-10-15

  The invention relates to compounds of general formula (I) wherein X is C=O or SO2, M is NR2 or O, and Q1 and Q2 are nitroxide-containing radicals, and their use as a Dynamic Nuclear Polarization (DNP) agent for polarizing an NMR-active spin of a nucleus of an analyte in Nuclear Magnetic Resonance (NMR) spectroscopy.

  该发明涉及一般式（I）的化合物，其中X为C=O或SO2，M为NR2或O，Q1和Q2为含氮氧自由基的基团，并且它们作为动态核极化（DNP）试剂用于极化核磁共振（NMR）光谱分析中的分析物核的NMR活跃自旋。
• [EN] THIRD GENERATION DENDRIMER, PROCESS FOR PRODUCTION THEREOF AND USE THEREOF<br/>[FR] DENDRIMÈRE DE TROISIÈME GÉNÉRATION, SON PROCÉDÉ DE PRODUCTION ET SON UTILISATION
  申请人：CONSEJO SUPERIOR INVESTIGACION

  公开号：WO2021028171A1

  公开（公告）日：2021-02-18

  The present invention discloses a third generation polyphosphorhydrazone (PPH) dendrimer peripherally functionalized with PROXYL radical units, by using a tyrosine amino acid (Tyr) as linker. The present invention also relates to the process of obtainment of said dendrimer and the use thereof as a magnetic resonance imaging (MRI) contrast agent.

  本发明披露了一种第三代聚磷酸酰肼（PPH）树状分子，其周边功能化了PROXYL自由基单元，通过使用酪氨酸氨基酸（Tyr）作为连接剂。本发明还涉及所述树状分子的制备过程以及其作为磁共振成像（MRI）对比剂的用途。
• HYDROXYLAMINE COMPOUNDS AND METHODS OF THEIR USE
  申请人：Patil Ghanshyam

  公开号：US20080280890A1

  公开（公告）日：2008-11-13

  The present disclosure provides compounds that include hydroxylamines of formula I or II, pharmaceutical compositions, and methods for their use. The methods utilize hydroxylamine compounds and/or their pharmaceutical compositions for the treatment of angiogenesis, hepatitis, complement-mediated pathologies, drusen-mediated pathologies, macular degeneration and certain other ophthalmic conditions, inflammation, arthritis, and related diseases and for the inhibition of complement activation.

  本公开提供了包括式I或II的羟胺化合物、制药组合物以及它们的使用方法。该方法利用羟胺化合物及/或其制药组合物治疗血管生成、肝炎、补体介导的病理、色斑介导的病理、黄斑变性和某些其他眼科疾病、炎症、关节炎和相关疾病，并抑制补体激活。