2-(1-Ethyl-but-3-enyl)-4,5-dihydro-oxazole | 107515-79-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 2-(1-Ethyl-but-3-enyl)-4,5-dihydro-oxazole
• 英文别名: 2-Hex-5-en-3-yl-4,5-dihydro-1,3-oxazole
• CAS: 107515-79-7
• 化学式: C₉H₁₅NO
• 分子量: 153.224
• InChiKey: UNSHLCQNHQNAMF-UHFFFAOYSA-N

物化性质

• 沸点：
  198.6±19.0 °C(Predicted)
• 密度：
  0.96±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(1-Ethyl-but-3-enyl)-4,5-dihydro-oxazole 、 苯基氯化硒 以 乙腈 为溶剂， 反应 2.0h， 以67%的产率得到1-(2-Chloro-ethyl)-3-ethyl-5-phenylselanylmethyl-pyrrolidin-2-one
  参考文献：
  名称：

  Organoselenium-induced cyclization of olefinic imidates and amides. Selective synthesis of lactams or iminolactones

  摘要：

  DOI：

  10.1021/jo00386a022

文献信息

• TOSHIMITSU AKIO; TERAO KEIJI; UEMURA SAKAE, J. ORG. CHEM., 52,(1987) N 10, 2018-2026
  作者：TOSHIMITSU AKIO、 TERAO KEIJI、 UEMURA SAKAE

  DOI：——

  日期：——
• CROSS-LINKED POLYMERS AND IMPLANTS DERIVED FROM ELECTROPHILICALLY ACTIVATED POLYOXAZOLINE
  申请人：Bender Analytical Holding B.V.

  公开号：EP2661283A2

  公开（公告）日：2013-11-13
• [EN] CROSS-LINKED POLYMERS AND IMPLANTS DERIVED FROM ELECTROPHILICALLY ACTIVATED POLYOXAZOLINE<br/>[FR] POLYMÈRES RÉTICULÉS ET IMPLANTS À BASE DE POLYOXAZOLINE ACTIVÉE DE MANIÈRE ÉLECTROPHILE
  申请人：BENDER ANALYTICAL HOLDING BV

  公开号：WO2012057628A2

  公开（公告）日：2012-05-03

  One aspect of the invention relates to a biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent, said electrophilically activated POX comprising m electrophilic groups; and said nucleophilic cross-linking agent comprising n nucleophilic groups, wherein the m electrophilic groups are capable of reaction with the n nucleophilic groups to form covalent bonds; wherein m≥2, n≥2 and m+n ≥5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m≥3; and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. The invention further relates to biocompatible medical products comprising such a cross-linked POX-polymer. Also provided is a kit for producing a biocompatible, cross-linked POX-polymer. The invention further provides a tissue adhesive medical product comprising at least 1% by weight of dry matter of EL-POX, said EL-POX comprising at least 2 electrophilic groups, including at least one pendant electrophilic group. The polymers according to the invention have excellent implant and/or sealing characteristics.