10-<4-(3-Hydroxy-propyl)-piperazino>-10,11-dihydro-dibenzothiepin | 16926-48-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫平类
• 英文名称: 10-<4-(3-Hydroxy-propyl)-piperazino>-10,11-dihydro-dibenzothiepin
• 英文别名: 3-[4-(10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazin-1-yl]-propan-1-ol；3-[4-(5,6-Dihydrobenzo[b][1]benzothiepin-5-yl)piperazin-1-yl]propan-1-ol
• CAS: 16926-48-0
• 化学式: C₂₁H₂₆N₂OS
• 分子量: 354.516
• InChiKey: CVUZIXLGMISYEM-UHFFFAOYSA-N

物化性质

• 沸点：
  499.9±45.0 °C(Predicted)
• 密度：
  1.193±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  52
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• A PHARMACEUTICAL COMPOSITION HAVING ANTIPSYCHOTIC, ANTIDEPRESSANT OR ANTIEPIIEPTIC ACTIVITY WITH REDUCED SIDE EFFECT
  申请人：N-Gene Research Laboratories Inc.

  公开号：EP2089032A1

  公开（公告）日：2009-08-19
• A PHARMACEUTICAL COMPOSITION HAVING ANTIPSYCHOTIC, ANTIDEPRESSANT OR ANTIEPILEPTIC ACTIVITY WITH REDUCED SIDE EFFECT
  申请人：N-Gene Research Laboratories Inc.

  公开号：EP2089032B1

  公开（公告）日：2010-12-15
• Prevention of obesity in antipsychotic, antidepressant and antiepileptic medication
  申请人：Nagy Peter Literati

  公开号：US20080108602A1

  公开（公告）日：2008-05-08

  O-(3-piperidino-2-hydroxypropyl)-nicotinic amidoxime or a pharmaceutically suitable acid addition salt thereof (BGP-15) can be used for the prevention or reduction of weight gain or obesity in a patient treated with an antipsychotic drug or an antidepressant drug or an antiepileptic drug.
• Prevention of Obesity in Antipsychotic, Antidepressant and Antiepileptic Medication
  申请人：Nagy Péter Literáti

  公开号：US20100311719A1

  公开（公告）日：2010-12-09

  O-(3-piperidino-2-hydroxypropyl)-nicotinic amidoxime or a pharmaceutically suitable acid addition salt thereof (BGP-15) can be used for the prevention or reduction of weight gain or obesity in a patient treated with an antipsychotic drug or an antidepressant drug or an antiepileptic drug.
• [EN] A PHARMACEUTICAL COMPOSITION HAVING ANTIPSYCHOTIC, ANTIDEPRESSANT OR ANTIEPIIEPTIC ACTIVITY WITH REDUCED SIDE EFFECT<br/>[FR] COMPOSITION PHARMACEUTIQUE DOTÉE D'UNE ACTIVITÉ ANTIPSYCHOTIQUE, ANTIDÉPRESSIVE OU ANTI-ÉPILEPTIQUE À EFFET SECONDAIRE RÉDUIT
  申请人：N GENE RES LAB INC

  公开号：WO2008053257A1

  公开（公告）日：2008-05-08

  [EN] The side effect leading to overweight or obesity in medication with a known antipsychotic, antidepressant or antiepileptic drug is reduced by the administration of O-(3- piperidino-2-hydroxy-1-propyl)-nicotinic amidoxime or a pharmaceutically acceptable acid addition salt thereof.
  [FR] Le surpoids ou l'obésité apparaissant comme effet secondaire connu d'une médication antipsychotique, antidépressive ou un anti-épileptique est réduit par l'administration d'amidoxine O-(3- pipéridino-2-hydroxy-1-propyl)-nicotinique ou d'un sel d'addition d'acides pharmaceutiquement acceptable de celui-ci.