(3R,7S,8aS)-8a-methyl-5-oxo-3-phenyl-7-propyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine | 1049705-13-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3R,7S,8aS)-8a-methyl-5-oxo-3-phenyl-7-propyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
• CAS: 1049705-13-6
• 化学式: C₁₇H₂₃NO₂
• 分子量: 273.375
• InChiKey: JRPRSKDOTOBOEB-KMFMINBZSA-N

反应信息

• 作为产物：
  描述：

  (3R,8aS)-7-allyl-6-(benzyloxycarbonyl)-3-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 在 palladium on activated charcoal ammonium formate 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 30.0h， 生成 (3R,7S,8aS)-8a-methyl-5-oxo-3-phenyl-7-propyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 、 (3R,7R,8aS)-8a-methyl-5-oxo-3-phenyl-7-propyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
  参考文献：
  名称：

  An Enantioselective Synthetic Route to cis-2,4-Disubstituted and 2,4-Bridged Piperidines

  摘要：

  A synthetic route to enantiopure cis-2,4-disubstituted and 2,4-bridged piperidines is reported, the key step being a stereoselective conjugate addition of an organocuprate to a phenylglycinol-derived unsaturated lactam bearing a substituent at the 8a-position.

  DOI：

  10.1021/jo801172b