tert-butyl 4-((3-amino-6-chloropyridin-2-yl)amino)piperidine-1-carboxylate | 1352624-82-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl 4-((3-amino-6-chloropyridin-2-yl)amino)piperidine-1-carboxylate
• 英文别名: Tert-butyl 4-[(3-amino-6-chloropyridin-2-yl)amino]piperidine-1-carboxylate
• CAS: 1352624-82-8
• 化学式: C₁₅H₂₃ClN₄O₂
• 分子量: 326.826
• InChiKey: AOPJIQJHWCKDEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  80.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Heteroaryl imidazolone derivatives as jak inhibitors
  申请人：Almirall, S.A.

  公开号：EP2397482A1

  公开（公告）日：2011-12-21

  New heteroaryl imidazolone derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

  新的杂环基咪唑酮衍生物具有化学结构式(I)，公开了它们的制备方法，包括它们的制药组合物以及它们作为Janus激酶（JAK）抑制剂在治疗中的用途。
• [EN] HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS<br/>[FR] DÉRIVÉS D'HÉTÉROARYLE IMIDAZOLONE EN TANT QU'INHIBITEURS DE JAK
  申请人：ALMIRALL SA

  公开号：WO2011157397A1

  公开（公告）日：2011-12-22

  New heteroaryl imidazolone derivatives having the chemical structure of formula (I) disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

  新的杂环芳基咪唑酮衍生物具有化学结构式（I）所示；以及它们的制备方法，包含它们的药物组合物以及它们作为Janus激酶（JAK）抑制剂在治疗中的用途。
• HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS
  申请人：Eastwood Paul Robert

  公开号：US20130089512A1

  公开（公告）日：2013-04-11

  New heteroaryl imidazolone derivatives having the chemical structure of formula (I) are disclosed, as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

  本发明公开了具有化学结构式（I）的新杂环芳基咪唑酮衍生物，以及它们的制备方法、包含它们的制药组合物和它们作为Janus激酶（JAK）抑制剂在治疗中的应用。
• [EN] HETEROCYCLIC COMPOUND AS DIACYLGLYCEROL KINASE INHIBITOR AND USE THEREOF<br/>[FR] COMPOSÉ HÉTÉROCYCLIQUE EN TANT QU'INHIBITEUR DE LA DIACYLGLYCÉROL KINASE ET SON UTILISATION<br/>[KO] 다이아실글리세롤 키나아제 저해제로서 헤테로사이클 화합물 및 이의 용도
  申请人：[en]LG CHEM, LTD.;[ko]주식회사 엘지화학

  公开号：WO2022114812A1

  公开（公告）日：2022-06-02

  본 발명은 다이아실글리세롤 키나아제 저해제 활성을 나타내는 화학식 1로 표시되는 헤테로사이클 화합물, 이를 활성성분으로 포함하는 약제학적 조성물 및 이의 용도에 관한 것이다.