1-Ethyl-4-aminomethyl-4-piperidinol | 19968-96-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Ethyl-4-aminomethyl-4-piperidinol
• 英文别名: 4-aminomethyl-1-ethyl-piperidin-4-ol；4-(aminomethyl)-1-ethyl-4-piperidinol；4-(Aminomethyl)-1-ethylpiperidin-4-ol
• CAS: 19968-96-8
• 化学式: C₈H₁₈N₂O
• 分子量: 158.244
• InChiKey: JQVGNYNZKLTMKF-UHFFFAOYSA-N

物化性质

• 沸点：
  95-97 °C(Press: 1.2 Torr)
• 密度：
  1.019±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• BICYCLIC HETEROCYCLIC DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF
  申请人：Agency for Science, Technology and Research

  公开号：US20140371199A1

  公开（公告）日：2014-12-18

  The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, Alzheimer's disease), as well as methods of treating these diseases.

  本发明涉及某些化合物（例如咪唑吡嗪、咪唑吡啶、咪唑吡嗪和咪唑嘧啶化合物），这些化合物作为MAP激酶相互作用激酶MNK2a、MNK2b、MNK1a和MNK1b的抑制剂。本发明还涉及包含这些化合物的药物组合物，以及利用这些化合物制备用于预防和治疗疾病（例如增生性疾病（例如癌症）、炎症性疾病、阿尔茨海默病）的药物的用途，以及治疗这些疾病的方法。
• Aromatic-Spiropiperidine oxazepinones (and thiones)
  申请人：A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation)

  公开号：EP0295833A1

  公开（公告）日：1988-12-21

  Novel aromatic-spiropiperidineoxazepinones and thiones exhibiting antihistamine activity are disclosed having the formula: wherein A represents an aromatic ring, selected from benzo when Z is carbon or pyrido[3,2-f] when Z is nitrogen either of which rings may be optionally substituted on carbon;     B is selected from oxygen or sulfur;     R¹ is selected from the group consisting of loweralkyl, cycloalkyl, cycloalkyl-loweralkyl or phenyl-loweralkyl of which phenyl may be optionally substituted;     R is selected from the group consisting of loweralkyl, cycloalkyl or phenyl-loweralkyl of which phenyl may be optionally substituted and the pharmaceutically acceptable salts thereof and novel chemical intermediates in the preparation thereof.

  本发明公开了具有抗组胺活性的新型芳香-硫代哌啶氧氮杂环庚酮和硫酮，其式如下 其中 A 代表芳香环，当 Z 为碳时，选自苯并环，当 Z 为氮时，选自吡啶并[3,2-f]环； B 选自氧或硫； R¹ 选自低烷基、环烷基、环烷基-低烷基或苯基-低烷基组成的组，其中苯基可被任选取代； R¹选自低级烷基、环烷基或苯基-低级烷基（其中苯基可被任选取代）组成的组，以及它们的药学上可接受的盐和制备它们的新型化学中间体。
• US4746655A
  申请人：——

  公开号：US4746655A

  公开（公告）日：1988-05-24
• US9908886B2
  申请人：——

  公开号：US9908886B2

  公开（公告）日：2018-03-06