N,N-Di-n-propylmethansulphenamid | 33696-22-9

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: N,N-Di-n-propylmethansulphenamid
• 英文别名: N-methylsulfanyl-N-propylpropan-1-amine
• CAS: 33696-22-9
• 化学式: C₇H₁₇NS
• 分子量: 147.285
• InChiKey: ZSBFNBVRFQGERU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N,N-diethylmethanesulfenamide 、 二正丙胺 生成 N,N-Di-n-propylmethansulphenamid
  参考文献：
  名称：

  硫（II）-氮键。第二部分 二氨基硫化物和亚磺酰胺的氨基转移

  摘要：

  将氨基转移反应应用于二氨基硫化物以及苯磺酰胺和甲烷磺酰胺中，可以得到高产率的硫（II）氮化合物。通过使用该反应可以方便地分离由仲胺和甲磺酰氯产生的混合物。的转氨基宝石-diamines已观察到。

  DOI：

  10.1039/j39710003141

文献信息

• BENZAZEPINE COMPOUNDS, CONJUGATES, AND USES THEREOF
  申请人：Silverback Therapeutics, Inc.

  公开号：EP3949969A2

  公开（公告）日：2022-02-09

  Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds are useful, among other things, in the treating of cancer and modulating TLR8. Additionally, benzazepine compounds incorporated into a conjugate with an antibody construct are described herein.

  本文公开了用于治疗癌症等疾病的苯并氮杂卓化合物、共轭物和药物组合物。所公开的苯并氮杂卓化合物主要用于治疗癌症和调节 TLR8。此外，本文还描述了与抗体构建体结合的苯并氮杂卓化合物。
• Organoaminosilanes and methods for making same
  申请人：Versum Materials US, LLC

  公开号：US10294250B2

  公开（公告）日：2019-05-21

  Organoaminosilanes, such as without limitation di-iso-propylaminosilane (DIPAS), are precursors for the deposition of silicon containing films such as silicon-oxide and silicon-nitride films. Described herein are methods to make organoaminosilane compounds, or other compounds such as organoaminodisilanes and organoaminocarbosilanes, via the catalytic hydrosilylation of an imine by a silicon source comprising a hydridosilane.

  有机氨基硅烷，例如但不限于二异丙氨基硅烷（DIPAS），是沉积氧化硅和氮化硅薄膜等含硅薄膜的前体。本文描述了通过包含氢基硅烷的硅源对亚胺进行催化氢硅烷化来制造有机氨基硅烷化合物或其他化合物如有机氨基二硅烷和有机氨基碳硅烷的方法。
• Eight-arm polyethylene glycol derivative, production method therefor, and modified bio-related substance thereof
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US10434182B2

  公开（公告）日：2019-10-08

  Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups Ec form a highly symmetrical octavalent group CORE0; Lc connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n1 to n8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k≥1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading. The eight-arm polyethylene glycol derivative has a centrosymmetric or approximately centrosymmetric structure, and leads to more precise control of the molecular weight in large-scale production and much narrower distribution of molecular weight for products. The modified bio-related substance thereby has a more uniform and controllable performance.

  本发明公开了一种八臂聚乙二醇（PEG）衍生物（式 I）、其生产方法及其改性生物相关物质。其中，一个四价基团 U 与四个三价基团 Ec 形成一个高度对称的八价基团 CORE0；Lc 将八价基团连接到八条具有多分散性或单分散性且聚合度为 n1 至 n8 的 PEG 链上；一条 PEG 链的末端与至少一个官能团 F 连接（k≥1）；所述 PEG 链和 F 之间可以直接连接（g=0），也可以通过连接基团 L0 与末端支化基团 G 间接连接（g=1）；后者提供了更多的反应位点，可以结合更多的药物分子，增加药物负载量。八臂聚乙二醇衍生物具有中心对称或近似中心对称结构，因此在大规模生产中可以更精确地控制分子量，产品的分子量分布也更窄。因此，改性生物相关物质的性能更均匀、更可控。
• FATTY ACID FUMARATE DERIVATIVES AND THEIR USES
  申请人：Catabasis Pharmaceuticals, Inc.

  公开号：EP2521447B1

  公开（公告）日：2017-06-14
• PRECURSORS AND FLOWABLE CVD METHODS FOR MAKING LOW-K FILMS TO FILL SURFACE FEATURES
  申请人：Versum Materials US, LLC

  公开号：EP3535436B1

  公开（公告）日：2021-05-12