1-<2-Methylmercapto-ethyl>-piperidin | 90227-88-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-<2-Methylmercapto-ethyl>-piperidin
• 英文别名: 1-(2-methylsulfanyl-ethyl)-piperidine；1-(2-methylthioethyl)piperidine；1-(2-Methylsulfanylethyl)piperidine
• CAS: 90227-88-6
• 化学式: C₈H₁₇NS
• mdl: MFCD28361800
• 分子量: 159.296
• InChiKey: WWYDZRWHQQRERV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] CTPS1 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE CTPS1 ET LEURS UTILISATIONS
  申请人：NIMBUS CLOTHO INC

  公开号：WO2022087634A1

  公开（公告）日：2022-04-28

  The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CPTS1, and the treatment of CPTS1-mediated disorders.

  本发明提供了化合物、其组合物以及使用它们抑制CPTS1和治疗CPTS1介导的疾病的方法。
• THIOALKYLAMINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
  申请人：Nihon Nohyaku Co., Ltd.

  公开号：EP1216988A1

  公开（公告）日：2002-06-26

  The present invention relates to a thioalkylamine derivative represented by general formula (I); and a process for production thereof: wherein each of R1 and R2 is H, (C1-C4)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl (C1-C4) alkyl, (substituted) phenyl, (substituted) phenyl(C1-C4) alkyl, or the like; each of R3 and R4 is H or a (C1-C4)alkyl group; each of R5 and R6 is H, (C1-C4)alkyl, a (substituted) phenyl group or a (substituted) phenyl(C1-C4)alkyl group; alternatively each of R1 and R2, R1 and R3 or R5, R3 and R4, R3 and R5, or R5 and R6 may together form lower alkylene; and R is (C1-C12)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl (C1-C4) alkyl, (substituted) phenyl, (substituted) phenyl (C1-C4)alkyl, a naphthyl group, a (substituted) aromatic heterocyclic, or the like.

  本发明涉及通式（I）所代表的硫代烷基胺衍生物及其生产工艺： 其中R1和R2各自为H、(C1-C4)烷基、(C3-C8)环烷基、(C3-C8)环烷基(C1-C4)烷基、(取代)苯基、(取代)苯基(C1-C4)烷基或类似物；R3和R4各自为H或(C1-C4)烷基；R5和R6各自为H、(C1-C4)烷基、(取代)苯基或(取代)苯基(C1-C4)烷基；或者，R1 和 R2、R1 和 R3 或 R5、R3 和 R4、R3 和 R5 或 R5 和 R6 可共同形成低级亚烷基；R 是 (C1-C12)烷基、(C3-C8)环烷基、(C3-C8)环烷基 (C1-C4) 烷基、（取代的）苯基、（取代的）苯基 (C1-C4)烷基、萘基、（取代的）芳香杂环基或类似基团。
• CXCR3 receptor agonists
  申请人：RECEPTOS LLC

  公开号：US11040954B1

  公开（公告）日：2021-06-22

  Compounds are provided having the structure of the following Formula I: where R, R1, R2, R3a and R3b are as defined herein. Pharmaceutical compositions comprising such compounds, as well as methods related to their manufacture and use, are also provided.

  所提供的化合物具有下式 I 的结构： 其中 R、R1、R2、R3a 和 R3b 如本文所定义。此外，还提供了包含此类化合物的药物组合物，以及与其制造和使用相关的方法。
• 7-SUBSTITUTED PYRROLE TRIAZINE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND PREPARATION METHOD THEREFOR AND USES THEREOF
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP3643717B1

  公开（公告）日：2021-06-02
• COMPOSITIONS AND METHODS FOR NON-TOXIC DELIVERY OF ANTIPROGESTINS
  申请人：Podolski Joseph S.

  公开号：US20130018027A1

  公开（公告）日：2013-01-17

  The subject matter of the instant invention is pertinent to the field of treatment of hormone-dependent conditions. New compounds and methods for treating these conditions are disclosed. Embodiments of the instant invention disclose methods for treating endometriosis, dysmenorrhea, breast cancer, uterine fibroids and endometrial hyperproliferation.