8-(4-fluoro-2-methylphenyl)-5,6,7,8-tetrahydro-2-[6-(4-methyl-1H-imidazol-1-yl)-1H-indol-2-yl]-[1,2,4]triazolo[1,5-a]pyridine | 1420202-38-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡啶类
• 英文名称: 8-(4-fluoro-2-methylphenyl)-5,6,7,8-tetrahydro-2-[6-(4-methyl-1H-imidazol-1-yl)-1H-indol-2-yl]-[1,2,4]triazolo[1,5-a]pyridine
• 英文别名: 8-(4-fluoro-2-methylphenyl)-2-[6-(4-methylimidazol-1-yl)-1H-indol-2-yl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine
• CAS: 1420202-38-5
• 化学式: C₂₅H₂₃FN₆
• 分子量: 426.496
• InChiKey: GTIFECDBXYVTQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  64.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY
  申请人：Cheng Jianjun

  公开号：US20120283214A1

  公开（公告）日：2012-11-08

  The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

  本发明涉及一种新型治疗环糊精含聚合物组合物，设计为小分子治疗药物输送的载体及其制药组合物。这些含环糊精的聚合物改善了药物的稳定性和溶解性，并在体内使用时减少了小分子治疗药物的毒性。此外，通过从各种连接剂和靶向配体中选择，这些聚合物提供了治疗剂的可控释放方法。本发明还涉及使用上述治疗组合物治疗主体的方法。本发明还涉及用于制造、许可或分发包含或涉及上述聚合物的工具包的制药业务方法。
• NOVEL SUBSTITUTED INDOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
  申请人：Janssen Pharmaceuticals, Inc.

  公开号：EP2731948B1

  公开（公告）日：2015-09-09
• US9115143B2
  申请人：——

  公开号：US9115143B2

  公开（公告）日：2015-08-25