N,N-bis-(6-methyl-pyridazin-3-ylmethyl)-3-(5-methyl-pyridin-2-yl)-5-(5-trifluoromethyl-tetrazol-1-yl)-benzamide | 1161859-11-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N,N-bis-(6-methyl-pyridazin-3-ylmethyl)-3-(5-methyl-pyridin-2-yl)-5-(5-trifluoromethyl-tetrazol-1-yl)-benzamide
• 英文别名: N,N-bis[(6-methylpyridazin-3-yl)methyl]-3-(5-methylpyridin-2-yl)-5-[5-(trifluoromethyl)tetrazol-1-yl]benzamide
• CAS: 1161859-11-5
• 化学式: C₂₇H₂₃F₃N₁₀O
• 分子量: 560.541
• InChiKey: JDJQYWCPEFJGCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  41
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  128
• 氢给体数：
  0
• 氢受体数：
  12

文献信息

• Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists
  申请人：Chen Li

  公开号：US20090163502A1

  公开（公告）日：2009-06-25

  Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R 1 is optionally substituted tetrazolyl, R 2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R 3 , R 4 , R 5 , R 6 R 7 and R 8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X 3 and/or a P2X 2/3 receptor antagonist and methods of making the compounds.

  式I的化合物：或其药用可接受的盐，其中，R1是可选择地取代的四唑基，R2是可选择地取代的苯基，可选择地取代的吡啶基或可选择地取代的噻吩基，而R3、R4、R5、R6、R7和R8的定义如本文所述。还提供了使用这些化合物治疗与P2X3和/或P2X2/3受体拮抗剂相关的疾病的方法，以及制备这些化合物的方法。
• TETRAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS
  申请人：Chen Li

  公开号：US20120015944A1

  公开（公告）日：2012-01-19

  Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R 1 is optionally substituted tetrazolyl, R 2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R 3 , R 4 , R 5 , R 6 R 7 and R 8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X 3 and/or a P2X 2/3 receptor antagonist and methods of making the compounds.

  公式I的化合物或其药学上可接受的盐，其中，R1是可选取代的四唑基，R2是可选取代的苯基，可选取代的吡啶基或可选取代的噻吩基，而R3、R4、R5、R6、R7和R8的定义如本文所述。还提供了使用这些化合物治疗与P2X3和/或P2X2/3受体拮抗剂相关的疾病的方法以及制备这些化合物的方法。
• Tetrazole-substituted arylamide derivatives and their use as P2x3 and/or P2x2/3 purinergic receptor antagonists
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2570407A1

  公开（公告）日：2013-03-20

  Benzamide compounds or pharmaceutically acceptable salts thereof for treating diseases associated with the P2X3 and/or a P2X2/3 receptor.

  苯甲酰胺化合物或其药学上可接受的盐，用于治疗与 P2X3 和/或 P2X2/3 受体相关的疾病。
• TETRAZOLE-SUBSTITUTED ARYLAMIDE DERIVATIVES AND THEIR USE AS P2X3 AND/OR P2X2/3 PURINERGIC RECEPTOR ANTAGONISTS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2570407B1

  公开（公告）日：2014-08-13
• US8048905B2
  申请人：——

  公开号：US8048905B2

  公开（公告）日：2011-11-01