[Pt(2,2-dimethyl-1,3-propylenediamine)Cl₂] | 28866-75-3

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: [Pt(2,2-dimethyl-1,3-propylenediamine)Cl₂]
• 英文别名: 2,2-Dimethylpropane-1,3-diamine;platinum(2+);dichloride；2,2-dimethylpropane-1,3-diamine;platinum(2+);dichloride
• CAS: 28866-75-3
• 化学式: C₅H₁₄Cl₂N₂Pt
• 分子量: 368.166
• InChiKey: VUDVUDBVYBBRCR-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  1.31
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [Pt(2,2-dimethyl-1,3-propylenediamine)Cl₂] 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 (NH2CH2C(CH3)2CH2NH2)dihydroxoplatinum(II)
  参考文献：
  名称：

  The hydrolysis products of cis-diamminedichloroplatinum(II) 6. A kinetic comparison of the cis- and trans-isomers and other cis-di(amine)di(chloro)platinum(II) compounds

  摘要：

  Di(amine)di(chloro)platinum(II) complexes react in aqueous acid solution to form an equilibrium mixture L2PtCl2 k-1 reversible kj L2PtCl(OH2)+ + Cl-. Values of k1, K-1 and the equilibrium constant K(T) (-k1/k-1) have been measured for the systems L2 = cis(NH3)2, trans(NH3)2, cis(py)2, en, RR-chxn, tn and Me2tn, with varying temperature and ionic strength (cis(NH3)2 only). At 25-degrees-C and I = 0.1 M, data for cis-PtCl2(NH3)2 are k1 = 5.18 x 10(-5) s-1 (DELTA-H# = 86.7 kJ mol-1, DELTA-S# = -36 J K mol-1), k1 = 7.68 x 10(-3) M-1 s-1 (DELTA-H# - 72.7, DELTA-S# = - 41) and K1 = 6.74 x 10(-3). Corresponding data for trans-PtCl2(NH3)2 are k1 = 1.90 x 10(-5) s-1 (DELTA-H# = 92.2, DELTA-S# = - 26), k-1 - 3.05 x 10(-2) M-1 s-1 (DELTA-H# = 85.7, DELTA-S# = + 14) and K1 = 6.22 x 10(-4). These data provide a kinetic explanation for the inactivity of the trans-isomer as an anti-cancer drug.

  DOI：

  10.1016/s0020-1693(00)80242-x
• 作为产物：
  描述：

  (NH2CH2C(CH3)2CH2NH2)dihydroxoplatinum(II) 在 sodium chloride 作用下， 以 高氯酸 为溶剂， 生成 [Pt(2,2-dimethyl-1,3-propylenediamine)Cl₂]
  参考文献：
  名称：

  The hydrolysis products of cis-diamminedichloroplatinum(II) 6. A kinetic comparison of the cis- and trans-isomers and other cis-di(amine)di(chloro)platinum(II) compounds

  摘要：

  Di(amine)di(chloro)platinum(II) complexes react in aqueous acid solution to form an equilibrium mixture L2PtCl2 k-1 reversible kj L2PtCl(OH2)+ + Cl-. Values of k1, K-1 and the equilibrium constant K(T) (-k1/k-1) have been measured for the systems L2 = cis(NH3)2, trans(NH3)2, cis(py)2, en, RR-chxn, tn and Me2tn, with varying temperature and ionic strength (cis(NH3)2 only). At 25-degrees-C and I = 0.1 M, data for cis-PtCl2(NH3)2 are k1 = 5.18 x 10(-5) s-1 (DELTA-H# = 86.7 kJ mol-1, DELTA-S# = -36 J K mol-1), k1 = 7.68 x 10(-3) M-1 s-1 (DELTA-H# - 72.7, DELTA-S# = - 41) and K1 = 6.74 x 10(-3). Corresponding data for trans-PtCl2(NH3)2 are k1 = 1.90 x 10(-5) s-1 (DELTA-H# = 92.2, DELTA-S# = - 26), k-1 - 3.05 x 10(-2) M-1 s-1 (DELTA-H# = 85.7, DELTA-S# = + 14) and K1 = 6.22 x 10(-4). These data provide a kinetic explanation for the inactivity of the trans-isomer as an anti-cancer drug.

  DOI：

  10.1016/s0020-1693(00)80242-x

文献信息

• Synthesis, cytotoxic activity and DNA interaction studies of new dinuclear platinum(<scp>ii</scp>) complexes with an aromatic 1,5-naphthyridine bridging ligand: DNA binding mode of polynuclear platinum(<scp>ii</scp>) complexes in relation to the complex structure
  作者：Bata Konovalov、Marija D. Živković、Jelena Z. Milovanović、Dragana B. Djordjević、Aleksandar N. Arsenijević、Ivana R. Vasić、Goran V. Janjić、Andjela Franich、Dragan Manojlović、Sandra Skrivanj、Marija Z. Milovanović、Miloš I. Djuran、Snežana Rajković

  DOI：10.1039/c8dt01946k

  日期：——

  effects on LLC1 and 4T1 cells, complexes Pt1 and Pt2 had significant cytotoxic activity toward CT26 cells. Complex Pt1 had a much lower IC50 value for activity on CT26 cells compared with cisplatin. In comparison with cisplatin, all dinuclear Pt1–Pt7 complexes showed lower cytotoxicity toward normal MSC and MRC-5 cells. In order to measure the amount of platinum(II) complexes taken up by the cells, we quantified

  通式为[Pt（L）Cl} 2（μ-1,5-nphe）]（ClO）的七个新型双核铂（II）配合物Pt1-Pt7的合成，光谱表征，细胞毒活性和DNA结合评估4）2（1,5-nphe是1,5-萘啶；而L是两个胺（Pt1）或一个双齿配位二胺：乙二胺（Pt2），（±）-1,2-丙二胺（Pt3），反式- （±）-1,2-二氨基环己烷（Pt4），1,3-丙二胺（Pt5），2,2-二甲基-1,3-丙二胺（Pt6）和1,3-戊二胺（Pt7））。评估了这些复合物对三种肿瘤细胞系，鼠结肠癌（CT26），鼠乳腺癌（4T1）和鼠肺癌（LLC1）和两种正常细胞系，鼠间充质干细胞（MSC）和人的体外细胞毒性活性成纤维细胞（MRC-5）细胞。MTT测定的结果表明，所有研究的复合物对4T1几乎没有细胞毒性作用，并且对LLC1细胞系的细胞毒性非常低。与对LLC1和4T1细胞的影响相反，复合物Pt1和Pt2对CT26细胞具有显着的细胞毒活性。复合物Pt1的IC
• Synthesis, spectroscopic and X-ray characterization of various pyrazine-bridged platinum(II) complexes: 1H NMR comparative study of their catalytic abilities in the hydrolysis of methionine- and histidine-containing dipeptides
  作者：Snežana Rajković、Marija D. Živković、Beata Warżajtis、Urszula Rychlewska、Miloš I. Djuran

  DOI：10.1016/j.poly.2016.06.011

  日期：2016.10

  (pz)-bridged Pt(II) complexes, [Pt(1,3-pd)Cl} 2 ( μ -pz)]Cl 2 ·LiCl ( 1 ) (1,3-pd = 1,3-propylenediamine), [Pt(2,2-diMe-1,3-pd)Cl} 2 ( μ -pz)]Cl 2 ·2[Li(H 2 O) 4 ]Cl·2H 2 O ( 2 ) (2,2-diMe-1,3-pd = 2,2-dimethyl-1,3-propylenediamine), [Pt(1,3-pnd)Cl} 2 ( μ -pz)](ClO 4 ) 2 ·H 2 O ( 3 ) (1,3-pnd = (±)-1,3-pentanediamine) and [Pt(1,3-pnd)Cl} 2 ( μ -pz)]Cl 2 ·2[Pt(1,3-pnd)Cl 2 ]·2H 2 O ( 4 ) have been

  摘要四种吡嗪（pz）桥连的Pt（II）配合物[Pt（1,3-pd）Cl} 2（μ-pz）] Cl 2·LiCl（1）（1,3-pd = 1,3 -丙二胺），[Pt（2,2-diMe-1,3-pd）Cl} 2（μ-pz）] Cl 2·2 [Li（H 2 O）4] Cl·2H 2 O（2） （2,2-diMe-1,3-pd = 2,2-二甲基-1,3-丙二胺），[Pt（1,3-pnd）Cl} 2（μ-pz）]（ClO 4）2 ·H 2 O（3）（1,3-pnd =（±）-1,3-戊二胺）和[Pt（1,3-pnd）Cl} 2（μ-pz）] Cl 2·2 [Pt合成了（1,3-pnd）Cl 2]·2H 2 O（4）。已经对化合物1-3进行了NMR和UV-Vis光谱表征，对配合物2和4进行了单晶X射线分析。4晶体中的原子分布表明存在一种无序现象，这可能归因于[Pt（1,3-pnd）Cl} 2（μ-pz）]
• In vitro and in vivoactivity of series of cationic dinuclearPt(II) complexes
  作者：Ivana Vasić、Snežana Rajković、Aleksandar Arsenijević、Marija Milovanović、Nebojša Arsenijević、Jelena Milovanović、Marija D. Živković

  DOI：10.1016/j.jinorgbio.2021.111619

  日期：2021.12

  expressing cells, complexes Pt5 and Pt6 exerted the highest antiproliferative effect. Complexes Pt1 and Pt2 exerted significant in vivo antitumour effects. These complexes reduced the growth of primary tumour and the incidence of lung and liver metastases without causing the significant hepato- and nephro- toxicity. Our data indicate considerable antitumour activity of platinum(II) complexes against CT26

  [Pt( L )Cl} 2 ( μ -X)] 2+类型的九种双核铂(II)配合物的抗肿瘤潜力（其中L代表两个NH 3或不同的双齿配位二胺配体-乙二胺，en；（ ±)-1,2-丙二胺，1,2-pn；异丁二胺，ibn；反式-(±)-1,2-二氨基环己烷，dach；1,3-丙二胺，2,2-二甲基； -1,3-丙二胺，2,2-diMe-1,3-pd；(±)-1,3-戊二胺，1,3-pnd，X是桥联吡嗪(pz)或哒嗪(pydz)配体）通过使用 CT26 细胞系和在免疫活性 BALB/c 小鼠中诱导的异位结肠癌肿瘤小鼠模型进行体外和体内测定来确定。本研究得出的结论是，复合物Pt1 、 Pt2和Pt7对小鼠结肠癌CT26细胞具有显着的体外细胞毒活性，同时所有这些复合物都显示出中等的细胞凋亡作用。复合物Pt1和Pt7将CT26细胞阻滞在细胞周期的G2/M期，而通过检测Ki67表达细胞进行评估，复合物Pt
• Crystal structure and proton NMR of (1,2-Bis(pyridin-2-yl)-ethane-N,N′)(2,2-dimethyl-1,3-diaminopropane-N1,N3)platinum(II) dichloride monohydrate
  作者：Wilfried Kleiböhmer、Bernt Krebs、Antonius T.M. Marcelis、Jan Reedijk、Johannis L. Van Der Veer

  DOI：10.1016/s0020-1693(00)91188-5

  日期：1983.1

  A and four formula units per unit cell. The structure has been solved by the heavy-atom method and refined by standard least-squares techniques to R = 0.031 and R w = 0.032 for 2079 independent reflections with I>1.96σ(I). The compound consists of cations [Pt(dmdap)(bpe)] 2+ , Cl − anions and water of crystallization. The square-planar coordinated Pt(II) ions have a mean PtN distance of 2.032(5) A

  摘要标题化合物[Pt（dmdap）（bpe）] Cl 2·H 2 O（bpe = 1,2-双（吡啶-2-基）乙烷; dmdap = 2,2-二甲基已经通过单晶X射线衍射研究了固态的-1,3-二氨基丙烷）。该化合物的性质已通过高分辨率质子NMR光谱在溶液中进行了研究。该化合物在正交晶空间群Pnma中结晶，其单元尺寸在-115°C下为a = 15.012（3）A，b = 13.555（3）A和c = 10.247（2）A，每个晶胞有四个分子式。对于2079次独立反射（I>1.96σ（I）），该结构已通过重原子方法求解，并通过标准最小二乘法改进为R = 0.031和R w = 0.032。该化合物由阳离子[Pt（dmdap）（bpe）] 2+，Cl-阴离子和结晶水组成。方平面配位的Pt（II）离子的平均PtN距离为2.032（5）A，NPtN角在87.3和92.0°之间。氯化物阴离子和水分
• Platinum complexes of aliphatic tricarboxylic acids
  申请人：American Cyanamid Company

  公开号：US04665210A1

  公开（公告）日：1987-05-12

  Platinum complexes of aliphatic tricarboxylic acids useful for inducing regression and/or palliation of cancer diseases in mammals.

  脂肪族三羧酸铂配合物可用于诱导哺乳动物癌症的退化和/或缓解。