tris[3-(allyldimethylsilyl)propyl]methylsilane | 893428-54-1

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: tris[3-(allyldimethylsilyl)propyl]methylsilane
• CAS: 893428-54-1
• 化学式: C₂₅H₅₄Si₄
• 分子量: 467.046
• InChiKey: GWPUNUDDJTXBDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.92
• 重原子数：
  29.0
• 可旋转键数：
  18.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  tris[3-(allyldimethylsilyl)propyl]methylsilane 在 cyclohexylborane 、 sodium hydroxide 、 双氧水 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 3.0h， 以73%的产率得到tris(3-((3-hydroxypropyl)dimethylsilyl)propyl)methylsilane
  参考文献：
  名称：

  Syntheses and Vero toxin-binding activities of carbosilane dendrimers periphery-functionalized with galabiose

  摘要：

  Carbosilane dendrimers bearing galabiose (Gal alpha 1-4Gal) with three, four, and six galabiose units at the periphery of the dendrimers were synthesized for use as artificial inhibitors against Shiga toxins (Stxs) produced by Escherichia coli O157:H7. The galabiose unit, prepared from penta-O-acetyl-beta-D-galactopyranose, was linked with carbosilane dendrimers of three shapes to afford acety I-protected glycodendrimers in good yields. De-O-acetylation of the clusters was carried out in the presence of NaOMe and then aq NaOH to give the desired three shapes of galabiose-coated carbosilane dendrimers. Their biological activities toward Stxs were evaluated by kinetic analysis, binding assays, and cytotoxic assays. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.03.042
• 作为产物：
  描述：

  二甲基一氯硅烷 、 甲基三烯丙基硅烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 dihydrogen hexachloroplatinate 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 24.0h， 以31%的产率得到tris[3-(allyldimethylsilyl)propyl]methylsilane
  参考文献：
  名称：

  Syntheses and Vero toxin-binding activities of carbosilane dendrimers periphery-functionalized with galabiose

  摘要：

  Carbosilane dendrimers bearing galabiose (Gal alpha 1-4Gal) with three, four, and six galabiose units at the periphery of the dendrimers were synthesized for use as artificial inhibitors against Shiga toxins (Stxs) produced by Escherichia coli O157:H7. The galabiose unit, prepared from penta-O-acetyl-beta-D-galactopyranose, was linked with carbosilane dendrimers of three shapes to afford acety I-protected glycodendrimers in good yields. De-O-acetylation of the clusters was carried out in the presence of NaOMe and then aq NaOH to give the desired three shapes of galabiose-coated carbosilane dendrimers. Their biological activities toward Stxs were evaluated by kinetic analysis, binding assays, and cytotoxic assays. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.03.042