(2R,3R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol | 552859-22-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (2R,3R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol
• 英文别名: (2R,3R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-ol
• CAS: 552859-22-0
• 化学式: C₂₆H₂₈O₅
• 分子量: 420.505
• InChiKey: ZUNGTVUTOQJPDE-JWQCQUIFSA-N

反应信息

• 作为反应物：
  描述：

  (2R,3R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol 在 二苯基膦叠氮化物 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 生成 (2S,3S)-3-Azido-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan
  参考文献：
  名称：

  Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity

  摘要：

  Conformationally restricted analogues of the central linker unit of bacterial methionyl tRNA synthetase (MRS) inhibitors have been prepared. The (IS,2R)-cyclopentylmethyl moiety was identified as the preferred cyclic linker, with significant diastereo- and enantio selectivity of activity. Combination of this linker with an optimal substituted aryl right-hand side has resulted in a compound with exceptionally good antibacterial activity against staphylococci and enterococci, including antibiotic resistant strains. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00093-3
• 作为产物：
  描述：

  Benzoic acid (2R,3R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 (2R,3R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol
  参考文献：
  名称：

  Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity

  摘要：

  Conformationally restricted analogues of the central linker unit of bacterial methionyl tRNA synthetase (MRS) inhibitors have been prepared. The (IS,2R)-cyclopentylmethyl moiety was identified as the preferred cyclic linker, with significant diastereo- and enantio selectivity of activity. Combination of this linker with an optimal substituted aryl right-hand side has resulted in a compound with exceptionally good antibacterial activity against staphylococci and enterococci, including antibiotic resistant strains. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00093-3

文献信息

• OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Wave Life Sciences Ltd.

  公开号：EP4022059A1

  公开（公告）日：2022-07-06
• [EN] OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF<br/>[FR] COMPOSITIONS D'OLIGONUCLÉOTIDES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2021071858A1

  公开（公告）日：2021-04-15

  Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.